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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Safety and efficacy of intracameral moxifloxacin for prevention of post-cataract endophthalmitis: Randomized controlled clinical trial

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Melega, Mathias V. [1] ; Alves, Monica [1] ; Cavalcanti Lira, Rodrigo Pessoa [2] ; da Silva, Iuri Cardoso [1] ; Ferreira, Bruna Gil [1] ; Assis Filho, Hermano L. G. [1] ; Pedreira Chaves, Fernando Rodrigo [1] ; Martini, Alexandre A. F. [1] ; Dias Freire, Livia Maria [1] ; dos Reis, Roberto [1] ; Leite Arieta, Carlos Eduardo [1]
Total Authors: 11
Affiliation:
[1] Univ Estadual Campinas, Sch Med Sci, Sao Paulo - Brazil
[2] Univ Fed Pernambuco, Recife, PE - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF CATARACT AND REFRACTIVE SURGERY; v. 45, n. 3, p. 343-350, MAR 2019.
Web of Science Citations: 3
Abstract

Purpose: To evaluate the safety and efficacy of intracameral (IC) 0.5% moxifloxacin in the prevention of post-cataract endophthalmitis. Setting: University of Campinas, Sao Paulo, Brazil. Design: Prospective randomized partially masked single-site clinical trial. Methods: Patients who had phacoemulsification were randomized into two groups in block sizes of 4. Group A (moxifloxacin group) consisted of patients who received an IC injection of 0.03 mL (150 mu g) of undiluted 0.5% moxiffoxacin at the end of surgery. Group B (control group) consisted of patients who received no IC medication. The postoperative prescription for both groups consisted of 0.5% moxifloxacin and 0.1% dexamethasone. Patients were monitored for 6 weeks after surgery. The primary outcome was the incidence of acute endophthalmitis in each group. Secondary outcomes were corrected distance visual acuity (CDVA), endothelial cell density (ECD), intraocular pressure (IOP), and central corneal thickness (CCT). Results: The study comprised 3640 eyes from 3640 patients. There were 1818 patients in Group A and 1822 patients in Group B. The incidence of endophthalmitis within 6 weeks of follow-up was 1 (0.05%) of 1818 eyes in the moxifloxacin group and 7 (0.38%) of 1822 eyes in the control group (P=.035). There was no significant difference in CDVA (P=.202), ECD (P=.482), IOP (P=.105), or CCT (P=.558). No ocular or systemic study related adverse events were observed. Conclusions: The IC injection of undiluted 0.5% moxifloxacin can be safely applied as the last step of phacoemulsification. It was found to be effective in reducing the risk for endophthalmitis. This study represents the first controlled randomized clinical trial to evaluate the safety and efficacy of IC moxifloxacin in the prevention of post-cataract endophthalmitis. (C) 2018 ASCRS and ESCRS (AU)

FAPESP's process: 14/19138-5 - Ocular tissue biobank implementation and investigation of new pathophysiological mechanisms of anterior segment eye diseases
Grantee:Mônica de Cássia Alves
Support Opportunities: Research Grants - Young Investigators Grants