The efficacy and safety of a whitening mouthrinse: randomized controlled clinical trial

• Grant number: 18/23892-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2019
• End date: July 31, 2022
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal Investigator: Alessandra Buhler Borges
• Grantee: Mariane Cintra Mailart
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil
• Associated scholarship(s): 20/13036-7 - Influence of hydrogen and carbamide peroxide-based bleaching agents on remineralization of white spots lesions, BE.EP.DR

Abstract

Several techniques and products for tooth bleaching are available, among them, the over-thecounter products have become popular. However, evidence based on in vivo studies about tooth color change and adverse effects for the continuous use is not well established in literature. Thus, the aim of this randomized clinical trial is to evaluate the efficacy and safety of 2.5% hydrogen peroxide-based whitening mouthrinses and patients' satisfaction with whitening outcomes. Forty-five volunteers will be recruited and allocated in three treatment groups: LWE (Listerine Whitening Extreme-2.5% Hydrogen peroxide); OPF (Opalescence PF-10% Carbamide peroxide-positive control) and PL (Placebo mouthrinse-negative control). Bleaching treatment will be performed 1x/day for 14 days during 2h for OPF, and 2x/day for 90 days for LWE and PL. Tooth color will be evaluated subjectively with Vitapan Classical and Vita Bleachedguide 3D-MASTER scales, and objectively with spectrophotometer, adopting CIE L*a*b* parameters. Tooth sensitivity will be evaluated with numerical scale associated to visualanalogue scale, and gingival condition with Löe index. The potential of enamel demineralization will be measured with enamel microbiopsies; enamel superficial morphology with scanning electron microscopy; and volunteers' satisfaction will be investigated with questionnaires. The analysis will be performed in different times of treatment. Data will be submitted to appropriate statistical analysis, according to normality test, and significance level of 5% will be adopted. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MAILART, MARIANE CINTRA; DOS SANTOS, KARINE CARVALHO; GOMES TORRES, CARLOS ROCHA; BORGES, ALESSANDRA BUHLER. Chemical behavior of 20%-22% carbamide peroxide gels in at-home bleaching: Randomized crossover in situ trial. Journal of Esthetic and Restorative Dentistry, v. N/A, p. 7-pg., 2022-10-06. (18/23892-8)