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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between decreased expression of estrogen receptor alpha, androgen receptor and phosphatase and tensin homolog immunoexpression in the canine prostate

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Author(s):
Kobayashi, Priscila E. [1] ; Rodrigues, Marcela M. P. [2] ; Gartner, Fatima [3] ; Rema, Alexandra [3] ; Fonseca-Alves, Carlos E. [1] ; Laufer-Amorim, Renee [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista, UNESP, FMVZ, Dept Clin Vet, Rua Prof Dr Walter Mauricio Correra S-N, BR-18618970 Botucatu, SP - Brazil
[2] Fac Med Botucatu, Dept Anestesiol, Av Prof Montenegro S-N, BR-18618687 Botucatu, SP - Brazil
[3] UP, ICBAS, Rua Jorge de Viterbo Ferreira 228, P-4050313 Porto - Portugal
Total Affiliations: 3
Document type: Journal article
Source: Pesquisa Veterinária Brasileira; v. 39, n. 1, p. 40-46, JAN 2019.
Web of Science Citations: 0
Abstract

Canine prostate gland is a hormonal dependent organ and its imbalance of estrogen and androgen receptor expressions are directly associated with the development of different diseases. Due to the lack of information regarding the behavior of the aforementioned receptors in canine prostate cancer (PC), this study aimed to identify estrogen receptor alpha (ERa), androgen receptor (AR), Ki67 and phosphatase and tensin homolog (PTEN) protein expressions in canine PC by immunohistochemistry. We found nuclear expression of ERa and AR in the epithelial cells of normal canine samples and a loss of protein expression in PC samples. Normal samples showed Ki67 expression in a few basal cells and the PC samples showed the highest mean of positive cells (253.1). Canine prostate cancer showed a high proliferative index, which was associated with independence of hormonal actuation. PTEN showed positive nuclear and cytoplasmic expression in normal canine samples and a loss in PC. Loss of ERa, AR and PTEN indicated that canine PC exhibits the same immunohistochemical phenotype as in human patients with PC resistant to hormonal therapy. Therefore, canine PC should be considered as a model to study human PC resistant to hormonal therapy. (AU)

FAPESP's process: 06/06523-1 - Canine prostatic epithelial atypia: molecular and immunophenotypic aspects
Grantee:Marcela Marcondes Pinto Rodrigues
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/16068-0 - Epigenetic evaluation of NKX3.1 and CDH1 and immunohistochemistry expression of c-myc, NKX3.1 and E-cadherin on tissue microarray (TMA) of pre-neoplastic and neoplastic prostate of dogs
Grantee:Renee Laufer Amorim
Support type: Regular Research Grants