| Full text | |
| Author(s): Show less - |
Guilherme, Joao Paulo L. F.
[1]
;
Egorova, Emiliya S.
[2]
;
Semenova, Ekaterina A.
[3, 4]
;
Kostryukova, Elena S.
[3]
;
Kulemin, Nickolay A.
[3]
;
Borisov, Oleg V.
[5, 3]
;
Khabibova, Sofya A.
[3]
;
Larin, Andrey K.
[3]
;
Ospanova, Elena A.
[3]
;
Pavlenko, Alexander V.
[3]
;
Lyubaeva, Ekaterina V.
[6]
;
Popov, Daniil V.
[6]
;
Lysenko, Evgeny A.
[6]
;
Vepkhvadze, Tatiana F.
[6]
;
Lednev, Egor M.
[6]
;
Govorun, Vadim M.
[3]
;
Generozov, Edward V.
[3]
;
Ahmetov, Ildus I.
[7, 2, 3, 8]
;
Lancha, Antonio H. Junior
[1]
Total Authors: 19
|
| Affiliation: | [1] Univ Sao Paulo, Sch Phys Educ & Sport, Dept Biodynam Human Body Movement, Lab Appl Nutr & Metab, Sao Paulo - Brazil
[2] Kazan State Med Univ, Lab Mol Genet, Kazan - Russia
[3] Fed Med Biol Agcy, Dept Mol Biol & Genet, Fed Res & Clin Ctr Phys Chem Med, Moscow - Russia
[4] Kazan Fed Univ, Dept Biochem, Kazan - Russia
[5] State Univ, Moscow Inst Phys & Technol, Moscow - Russia
[6] Russian Acad Sci, Inst Biomed Problems, Lab Exercise Physiol, Moscow - Russia
[7] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside - England
[8] St Petersburg Res Inst Phys Culture, Sports Genet Lab, St Petersburg - Russia
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | JOURNAL OF STRENGTH AND CONDITIONING RESEARCH; v. 33, n. 3, p. 691-700, MAR 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
Guilherme, JPLF, Egorova, ES, Semenova, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Ospanova, EA, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Govorun, VM, Generozov, EV, Ahmetov, II, and Lancha Junior, AH. The A-allele of the FTO gene rs9939609 polymorphism is associated with decreased proportion of slow oxidative muscle fibers and over-represented in heavier athletes. J Strength Cond Res 33(3): 691-700, 2019-The purpose of this study was to explore the frequency of the FTO T > A (rs9939609) polymorphism in elite athletes from 2 cohorts (Brazil and Russia), as well as to find a relationship between FTO genotypes and muscle fiber composition. A total of 677 athletes and 652 nonathletes were evaluated in the Brazilian cohort, whereas a total of 920 athletes and 754 nonathletes were evaluated in the Russian cohort. It was found a trend for a lower frequency of A/A genotype in long-distance athletes compared with nonathletes (odds ratio {[}OR]: 0.65; p = 0.054). By contrast, it was found an increased frequency of the A-allele in Russian power athletes. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a Russian power athlete compared with matched nonathletes (OR: 1.45; p = 0.002). Different from that observed in combat sports athletes of lighter weight categories, the A-allele was also over-represented in combat sports athletes of heavier weight categories. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a combat sports athlete of heavier weight categories compared with nonathletes (OR: 1.79; p = 0.018). Regarding the muscle fibers, we found that carriers of the A/A genotype had less slow-twitch muscle fibers than T-allele carriers (p = 0.029). In conclusion, the A/A genotype of the FTO T > A polymorphism is under-represented in athletes more reliant on a lean phenotype and associated with decreased proportion of slow-twitch muscle fibers, while is over-represented in strength and heavier athletes. (AU) | |
| FAPESP's process: | 12/22516-6 - Polygenic profile of Brazilian athletes: distribution of polymorphisms associated with physical performance |
| Grantee: | João Paulo Limongi França Guilherme |
| Support Opportunities: | Scholarships in Brazil - Doctorate |