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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The role of sphingosine-1-phosphate in skeletal muscle: Physiology, mechanisms, and clinical perspectives

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Author(s):
Cordeiro, Andre V. [1] ; Silva, Vagner R. R. [1] ; Pauli, Jose R. [1, 2] ; da Silva, Adelino S. R. [3, 4] ; Cintra, Dennys E. [5] ; Moura, Leandro P. [1, 2] ; Ropelle, Eduardo R. [1, 6, 2]
Total Authors: 7
Affiliation:
[1] Univ Campinas UNICAMP, Sch Appl Sci, Lab Mol Biol Exercise LaBMEx, Limeira, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Appl Sci, Ctr Res Sport Sci CEPECE, Limeira, SP - Brazil
[3] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Postgrad Program Rehabil & Funct Performance, Ribeirao Preto, SP - Brazil
[5] Univ Estadual Campinas, Sch Appl Sci, Lab Nutr Genom LabGeN, Limeira, SP - Brazil
[6] Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Campinas, SP - Brazil
Total Affiliations: 6
Document type: Review article
Source: Journal of Cellular Physiology; v. 234, n. 7, p. 10047-10059, JUL 2019.
Web of Science Citations: 1
Abstract

Sphingolipids were discovered more than a century ago and were simply considered as a class of cell membrane lipids for a long time. However, after the discovery of several intracellular functions and their role in the control of many physiological and pathophysiological conditions, these molecules have gained much attention. For instance, the sphingosine-1-phosphate (S1P) is a circulating bioactive sphingolipid capable of triggering strong intracellular reactions through the family of S1P receptors (S1PRs) spread in several cell types and tissues. Recently, the role of S1P in the control of skeletal muscle metabolism, atrophy, regeneration, and metabolic disorders has been widely investigated. In this review, we summarized the knowledge of S1P and its effects in skeletal muscle metabolism, highlighting the role of S1P/S1PRs axis in skeletal muscle regeneration, fatigue, ceramide accumulation, and insulin resistance. Finally, we discussed the physical exercise role in S1P/S1PRs signaling in skeletal muscle cells, and how this nonpharmacological strategy may be prospective for future investigations due to its ability to increase S1P levels. (AU)

FAPESP's process: 18/07634-9 - Evaluation of mitonuclear imbalance and UPRmt in the skeletal muscle of exercise mice: The role JNK and PKR.
Grantee:Eduardo Rochete Ropelle
Support Opportunities: Regular Research Grants
FAPESP's process: 11/09656-0 - Characterization of hypothalamic S1PR1 in the control of food intake in rodents
Grantee:Eduardo Rochete Ropelle
Support Opportunities: Research Grants - Young Investigators Grants