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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heat stress reduces Eimeria spp. infection and interferes with C. perfringens infection via activation of the hypothalamic-pituitary-adrenal axis

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Author(s):
Calefi, Atilio Sersun [1] ; de Queiroz Nunes, Catarina Augusta [1] ; da Silva Fonseca, Juliana Garcia [1] ; Quinteiro-Filho, Wanderley Moreno [1] ; Piantino Ferreira, Antonio Jose [1] ; Palermo-Neto, Joao [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Neuroimmunomodulat Res Grp, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Research in Veterinary Science; v. 123, p. 273-280, APR 2019.
Web of Science Citations: 0
Abstract

Heat stress has a relevant effect on animal health and productivity. Stress and environmental changes can contribute to disease development, such as avian necrotic enteritis (NE). The goal of this study was to analyze the effects of heat stress applied to broiler chickens in an experimental model of co-infection with Clostridium perfringens and Eimeria spp. Therefore, the current study was designed to analyze the effect of heat stress to broiler chickens in an experimental model of infection or co-infection with Clostridium perfringens and Eimeria spp. C. perfringens was given in the poultry feed and the Eimeria infection was induced by gavage with a live oocysts vaccine dose 30 times higher than the manufacturer recommendation. We observed a reduction in the secretory IgA concentration in the jejunum and ileum in heat-stressed chickens compared to non-stressed chickens. Decreased maximum scores of intestinal necrosis, crypt abscesses and transmural lesions were observed in the heat-stressed chickens co-infected and infected with Eimeria compared to the respective unstressed groups. Heat stress caused an increase the intestinal lesion scores in chickens infected with C. perfringens only. The crypt depth was greater in chickens from the heat-stressed groups compared to the non-stressed groups. We also demonstrated that HS decreased infection and/or Eimeria development in the intestinal epithelium, reducing the harmful potential of C. perfringens. (AU)

FAPESP's process: 12/03103-2 - Evaluation of heat stress on the development of necrotic enteritis due to Clostridium perfringens in broilers
Grantee:Atilio Sersun Calefi
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/17408-2 - Effects of heat stress on immunity of broilers in an experimental model of avian necrotic enteritis
Grantee:Atilio Sersun Calefi
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 09/51886-3 - Neuroimmunomodulation: drugs, stress and cytokines on nervous, endocrine and immune systems relationships
Grantee:João Palermo Neto
Support Opportunities: Research Projects - Thematic Grants