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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO2-Drive to Breathe

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Author(s):
Patrone, Luis Gustavo A. [1] ; Duarte, Jaime B. [1] ; Bicego, Kenia Cardoso [1] ; Steiner, Alexandre A. [2] ; Romanovsky, Andrej A. [3] ; Gargaglioni, Luciane H. [1]
Total Authors: 6
Affiliation:
[1] UNESP, Fac Agr & Vet Sci, Dept Anim Morphol & Physiol, Rod Prof Paulo Donato Castellane S-N, BR-14870000 Jaboticabal, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508090 Sao Paulo - Brazil
[3] St Josephs Hosp, Trauma Res, Thermoregulat & System Inflammat Lab FeverLab, Phoenix, AZ 85013 - USA
Total Affiliations: 3
Document type: Journal article
Source: PHARMACEUTICALS; v. 12, n. 1 JAN 24 2019.
Web of Science Citations: 0
Abstract

Receptors of the transient receptor potential (TRP) channels superfamily are expressed in many tissues and have different physiological functions. However, there are few studies investigating the role of these channels in cardiorespiratory control in mammals. We assessed the role of central and peripheral TRPV1 receptors in the cardiorespiratory responses to hypoxia (10% O-2) and hypercapnia (7% CO2) by measuring pulmonary ventilation ( V E ), heart rate (HR), mean arterial pressure (MAP) and body temperature (Tb) of male Wistar rats before and after intraperitoneal (AMG9810 {[}2.85 mu g/kg, 1 mL/kg]) or intracebroventricular (AMG9810 {[}2.85 mu g/kg, 1 mu L] or AMG7905 {[}28.5 mu g/kg, 1 mu L]) injections of TRPV1 antagonists. Central or peripheral injection of TRPV1 antagonists did not change cardiorespiratory parameters or Tb during room air and hypercapnic conditions. However, the hypoxic ventilatory response was exaggerated by both central and peripheral injection of AMG9810. In addition, the peripheral antagonist blunted the drop in Tb induced by hypoxia. Therefore, the current data provide evidence that TRPV1 channels exert an inhibitory modulation on the hypoxic drive to breathe and stimulate the Tb reduction during hypoxia. (AU)

FAPESP's process: 16/24577-3 - Neuroanatomical and functional alterations of the respiratory system during sleep and wakefulness in an experimental model for Alzheimer's disease
Grantee:Luciane Helena Gargaglioni Batalhão
Support type: Regular Research Grants
FAPESP's process: 15/24785-2 - The role of TRPV1 channels in the cardiorespiratory responses to hypercapnia and hypoxia in unanaesthetized Wistar rats
Grantee:Jaime Bizarri Duarte
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/05318-0 - Developmental consequences of intrauterine exposure to cannabinoids: impact on the cardiorespiratory system and sleep-wake cycle
Grantee:Luis Gustavo Alexandre Patrone
Support type: Scholarships in Brazil - Doctorate