Britos, Tatiane N.
Castro, Carlos E.
Bertassoli, Bruno M.
Fonseca, Fernando L. A.
Ferreira, Fabio F.
Haddad, Paula S.
Total Authors: 7
 Univ Fed Sao Paulo, Dept Chem, Diadema, SP - Brazil
 Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
 FMABC, Santo Andre, SP - Brazil
Total Affiliations: 3
Materials Science & Engineering C-Materials for Biological Applications;
Web of Science Citations:
This article describes the synthesis, characterization and in vivo cytotoxic evaluation of thiol-functionalized superparamagnetic iron oxide magnetic nanoparticles (SPIONs). They have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. Fe3O4 nanoparticles were synthesized by coprecipitation of iron salts and coated with L-cysteine. The physicochemical, morphological, and magnetic properties of Cys-Fe3O4 nanoparticles were characterized by different experimental techniques. To evaluate their applicability in nanomedicine we evaluated their cytotoxicity using Balb/C mice. The results show that Cys-SPIONs are good candidates as nanocarriers in biomedical applications. (AU)