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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles

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Britos, Tatiane N. [1] ; Castro, Carlos E. [2] ; Bertassoli, Bruno M. [3] ; Petri, Giuliana [3] ; Fonseca, Fernando L. A. [1, 3] ; Ferreira, Fabio F. [2] ; Haddad, Paula S. [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Dept Chem, Diadema, SP - Brazil
[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
[3] FMABC, Santo Andre, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Materials Science & Engineering C-Materials for Biological Applications; v. 99, p. 171-179, JUN 2019.
Web of Science Citations: 1

This article describes the synthesis, characterization and in vivo cytotoxic evaluation of thiol-functionalized superparamagnetic iron oxide magnetic nanoparticles (SPIONs). They have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. Fe3O4 nanoparticles were synthesized by coprecipitation of iron salts and coated with L-cysteine. The physicochemical, morphological, and magnetic properties of Cys-Fe3O4 nanoparticles were characterized by different experimental techniques. To evaluate their applicability in nanomedicine we evaluated their cytotoxicity using Balb/C mice. The results show that Cys-SPIONs are good candidates as nanocarriers in biomedical applications. (AU)

FAPESP's process: 11/19924-2 - Study and development of advanced novel materials: electronic, magnetic and nanostructured: an interdisciplinary approach
Grantee:Carlos Rettori
Support type: Research Projects - Thematic Grants
FAPESP's process: 15/26233-7 - Synthesis and structural characterization of cocrystals for application as sunscreen and antioxidants of topical use
Grantee:Fabio Furlan Ferreira
Support type: Regular Research Grants
FAPESP's process: 17/15061-6 - Preparation, Characterization and Biological Essay of Nanostructured Materials Based on Superparamagnetic Metallic and Bimetallic Nanoparticles
Grantee:Paula Silvia Haddad Ferreira
Support type: Regular Research Grants
FAPESP's process: 16/22221-7 - Comparative study between Paullinia cupana, PC-18 and magnesium on the solid Ehrlich tumor: antitumor, antifatigue and antioxidant action analysis
Grantee:Felipe Ko Chen
Support type: Scholarships in Brazil - Scientific Initiation