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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Annexin A1 peptide and endothelial cell-conditioned medium modulate cervical tumorigenesis

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Author(s):
Cardin, Laila Toniol [1] ; Prates, Janesly [1] ; da Cunha, Bianca Rodrigues [2] ; Tajara, Eloiza Helena [2] ; Oliani, Sonia Maria [1] ; Rodrigues-Lisoni, Flavia Cristina [3]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biosci Humanities & Exact Sci, Sao Jose Do Rio Preto - Brazil
[2] Sch Med Sao Jose Do Rio Preto, Dept Mol Biol, Sao Jose Do Rio Preto - Brazil
[3] Sao Paulo State Univ Unesp, Sch Engn, Ilha Solteira - Brazil
Total Affiliations: 3
Document type: Journal article
Source: FEBS OPEN BIO; v. 9, n. 4, p. 668-681, APR 2019.
Web of Science Citations: 0
Abstract

Cervical cancer is one of the leading causes of cancer death in women worldwide, and its tumorigenesis can be influenced by the microenvironment. The anti-inflammatory protein annexin A1 (ANXA1) has been reported to be associated with cancer progression and metastasis, suggesting that it plays a role in regulating tumour cell proliferation. Here, we examined the effect of the N-terminal peptide Ac2-26 of ANXA1 on the HaCaT cell line (normal) and HeLa cell line (cervical cancer) co-cultured with endothelium cell-conditioned medium (HMC). Treatment with Ac2-26 decreased proliferation and increased motility of cervical cancer cells, but did not affect cellular morphology or viability. Combined HMC stimulus and Ac2-26 treatment resulted in an increase in apoptotic HeLa cells, upregulated expression of MMP2, and downregulated expression of COX2, EP3 and EP4. In conclusion, Ac2-26 treatment may modulate cellular and molecular mechanisms underlying cervical carcinogenesis. (AU)

FAPESP's process: 16/02012-4 - Evaluation of the immunomodulatory activity of annexin A1 protein in the regulation of inflammatory disorders of the gastrointestinal system: studies in vivo and in vitro experimental models
Grantee:Sonia Maria Oliani
Support Opportunities: Regular Research Grants
FAPESP's process: 13/24083-2 - Research of modulating the anti-inflammatory protein Annexin A1 in different cancer cells of the cervix
Grantee:Flávia Cristina Rodrigues Lisoni
Support Opportunities: Regular Research Grants