Assessment of surfactants on performance of molecularly imprinted polymer toward adsorption of pharmaceutical

Author(s)

Santos da Silva, Ricky Cassio ^[1] ; Santos, Matheus Nishikawa ^[1] ; Pires, Bruna Carneiro ^[1] ; Fonseca Dinali, Laise Aparecida ^[1] ; Cajamarca Suquila, Fabio Antonio ^[2] ; Teixeira Tarley, Cesar Ricardo ^{[3, 2]} ; Borges, Keyller Bastos ^[1]

Affiliation

^[1] Univ Fed Sao Joao del Rei, Dept Ciencias Nat, Campus Dom Bosco, Praca Dom Helvecio 74, BR-36301160 Sao Joao Del Rei, MG - Brazil

^[2] Univ Estadual Campinas UNICAMP, Inst Nacl Ciencia & Tecnol Bioanalit INCTBio, Inst Quim, Dept Quim, Cidade Univ Zeferino Vaz S-N, BR-13083861 Campinas, SP - Brazil

^[3] Univ Estadual Londrina, Dept Quim, Ctr Ciencias Exatas, Rodovia Celso Garcia Cid, PR 445, Km 380, BR-86050482 Londrina, Parana - Brazil

• Document type: Journal article
• Source: JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING; v. 7, n. 2 APR 2019.
• Web of Science Citations: 2

Abstract

Double imprinting process is fundamental to improvements in the adsorptive capacity of the molecularly imprinted polymers (MIP), but the effect of the surfactant type on adsorptive properties of the double-imprinted polymers are poorly understood. Thus, MIP to potassium diclofenac (PD) were developed and evaluated for their adsorbent properties. Polymers were characterized by infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetry (TGA) and textural properties. Kinetic studies performed at pH 6 showed the best fit (R-2 = 0.999) using a pseudo-second-order model. Adsorptive capacities toward PD of polymer using benzalkonium chloride (BC), sodium dodecylsulfate (SDS) and Triton X-100 (TT-X-100) were found to be 1.82 mg g(-1), 1.12 mg g(-1) and 0.51 mg g(-1), respectively. MIP presented adsorptive capacity of 0.42 mg g(-1), while for no template (NIP) 0.35 mg g(-1). Equilibrium adsorption data were best fitted with Freundlich isotherm for MIP-SDS, single-site Langmuir-Freundlich for MIP and dual-site for MIP-BC, MIP-TT-X-100 and NIP. Selectivity study proved that all the polymers had better binding capacity towards PD, with good selectivity and affinity over other drugs. This study showed that the addition of surfactant influenced the adsorbent properties of the material, being the MIP-BC the polymer with larger pore size, enhancing consequently the mass transfer of the DP toward the sorbent sites, so it presented better adsorption capacity. (AU)

• FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
• Grantee: Marco Aurelio Zezzi Arruda
• Support Opportunities: Research Projects - Thematic Grants