Increased levels of plasma IL-1b and BDNF can predict resistant depression patients

Author(s)

Uint, Luciana ^[1] ; Bastos, Gisele Medeiros ^[1] ; Thurow, Helena Strelow ^[2] ; Borges, Jessica Bassani ^{[2, 1]} ; Crespo Hirata, Thiago Dominguez ^[2] ; Dias Franca, Joao Itolo ^[1] ; Hirata, Mario Hiroyuki ^{[2, 1]} ; de Moraes Rego Sousa, Mamanda Guerra ^[1]

Affiliation

^[1] Dante Pazzanese Inst Cardiol, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Revista da Associação Médica Brasileira; v. 65, n. 3, p. 361-369, MAR 2019.
• Web of Science Citations: 0

Abstract

BACKGROUND: There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result in Coronary Artery Disease occurrence. OBJECTIVE: This study aimed to compare the subclinical atherosclerosis markers, inflammatory profile, and BDNF production in Resistant Depression (RD) or Bipolar Affective Disorder (BAD) patients under conventional treatment. METHODS: The population evaluated was comprised of 34 RD, 43 BAD, and 41 controls. Subclinical atherosclerosis markers were evaluated using ultrasonography, tomography, and exercise stress test. Plasma concentrations of TNF alpha, IL-1 beta, IL-6, and BDNF were measured using Luminex100 (TM). The usCRP concentration was measured using turbidimetric immunoassay. IL1B, IL6, and TNFA expression were determined using TaqMan (R). For the statistical analysis, the significance level was established at p<0.05. RESULTS: Concerning subclinical atherosclerosis markers, only O2 consumption was reduced in the BAD group (p = 0.001). Although no differences were found in gene expression, BDNF and IL-1 beta plasma concentration was increased in the RD group (p = 0.002 and p = 0.005, respectively) even with an antidepressant treatment, which suggests that these drugs have no effect in IL-1 beta secretion and that the inflammasome may play a role in therapy response. CONCLUSION: Taken together, both BDNF and IL-1 beta plasma concentrations could be used to the early identification of RD patients. (AU)

• FAPESP's process: 11/22000-7 - Evaluation of plasma levels of C-reactive protein, interleukins and markers of subclinical atherosclerosis in patients with refractory unipolar depression or bipolar affective disorder
• Grantee: Amanda Guerra de Moraes Rego Souza
• Support type: Regular Research Grants