| Full text | |
| Author(s): |
Uint, Luciana
[1]
;
Bastos, Gisele Medeiros
[1]
;
Thurow, Helena Strelow
[2]
;
Borges, Jessica Bassani
[2, 1]
;
Crespo Hirata, Thiago Dominguez
[2]
;
Dias Franca, Joao Itolo
[1]
;
Hirata, Mario Hiroyuki
[2, 1]
;
de Moraes Rego Sousa, Mamanda Guerra
[1]
Total Authors: 8
|
| Affiliation: | [1] Dante Pazzanese Inst Cardiol, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Pharmaceut Sci, Sao Paulo, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | Revista da Associação Médica Brasileira; v. 65, n. 3, p. 361-369, MAR 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
SUMMARY BACKGROUND: There is no strong evidence on the link between inflammatory profile and pattern of drug treatment response in depressive patients that could result in Coronary Artery Disease occurrence. OBJECTIVE: This study aimed to compare the subclinical atherosclerosis markers, inflammatory profile, and BDNF production in Resistant Depression (RD) or Bipolar Affective Disorder (BAD) patients under conventional treatment. METHODS: The population evaluated was comprised of 34 RD, 43 BAD, and 41 controls. Subclinical atherosclerosis markers were evaluated using ultrasonography, tomography, and exercise stress test. Plasma concentrations of TNFα, IL-1β, IL-6, and BDNF were measured using Luminex100™. The usCRP concentration was measured using turbidimetric immunoassay. IL1B, IL6, and TNFA expression were determined using TaqMan®. For the statistical analysis, the significance level was established at p<0.05. RESULTS: Concerning subclinical atherosclerosis markers, only O2 consumption was reduced in the BAD group (p = 0.001). Although no differences were found in gene expression, BDNF and IL-1β plasma concentration was increased in the RD group (p = 0.002 and p = 0.005, respectively) even with an antidepressant treatment, which suggests that these drugs have no effect in IL-1β secretion and that the inflammasome may play a role in therapy response. CONCLUSION: Taken together, both BDNF and IL-1β plasma concentrations could be used to the early identification of RD patients. (AU) | |
| FAPESP's process: | 11/22000-7 - Evaluation of plasma levels of C-reactive protein, interleukins and markers of subclinical atherosclerosis in patients with refractory unipolar depression or bipolar affective disorder |
| Grantee: | Amanda Guerra de Moraes Rego Souza |
| Support Opportunities: | Regular Research Grants |