Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis

Full text
Author(s):
Show less -
Belangero, Sintia Iole [1, 2] ; Ota, Vanessa Kiyomi [1] ; Gadelha, Ary [3, 2] ; Berberian, Arthur Almeida [3, 2] ; de Assuncao-Leme, Idaiane Batista [3, 2] ; Noto, Cristiano [3, 2] ; Christofolini, Denise Maria [1, 4] ; Bellucco, Fernanda Teixeira [1] ; Santoro, Marcos Leite [1, 3, 2] ; Mazzotti, Diego Robles [5] ; Zugman, Andre [3, 2] ; Melaragno, Maria Isabel [1] ; Cardoso Smith, Marilia Arruda [1] ; Pellegrino, Renata [6] ; Hakonarson, Hakon [6] ; Cordeiro, Quirino [7] ; Moretti, Patricia Natalia [1, 8] ; Bressan, Rodrigo Affonseca [3, 2] ; Mari, Jair de Jesus [3] ; Jackowski, Andrea Parolin [3, 2]
Total Authors: 20
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, LiNC, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo - Brazil
[4] Human Reprod & Genet Ctr, Dept Collect Hlth, Fac Med ABC, Santo Andre - Brazil
[5] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA
[6] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 - USA
[7] Santa Casa Sch Med Sci, Dept Psiquiatria, Sao Paulo - Brazil
[8] Univ Brasilia UNB, Fac Med, Brasilia, DF - Brazil
Total Affiliations: 8
Document type: Journal article
Source: PSYCHIATRY RESEARCH; v. 274, p. 391-394, APR 2019.
Web of Science Citations: 0
Abstract

We investigated the role of DGCR2, a corticogenesis-related gene, on schizophrenia (SZ) and its subphenotypes, including brain morphology. A total of 221 SZ patients, 263 controls and 70 antipsychotic-naive first episode of psychosis (FEP) were genotyped for 17 DGCR2 polymorphisms. While no association between DGCR2 polymorphisms and SZ was found, the missense variant rs2072123 was associated to left rostral anterior cingulate thickness, showing that DGCR2 seems not to be associated directly with the SZ but might be influencing the brain morphology. We also showed a DGCR2 downregulation in SZ patients when compared to controls and FEP. (AU)

FAPESP's process: 16/04983-7 - Neuroimaging, genomics, transcriptomics and epigenomics: dealing with big data toward an integrative model of mental disorders
Grantee:Jair de Jesus Mari
Support type: Research Grants - eScience and Data Science Program - Regular Program Grants
FAPESP's process: 17/25016-8 - INVESTIGATION OF THE TREATMENT RESPONSE OF SCHIZOPHRENIA WITH RISPERIDONE: A PHARMACOGENETICS STUDY IN A COHORT OF FIRST EPISODE OF PSYCHOSIS PATIENTS
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants
FAPESP's process: 10/08968-6 - INVESTIGATION OF GENETIC AND EPIGENETIC MARKERS: A TRANSLATIONAL APPROACH FOR SCHIZOPHRENIA TREATMENT
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants
FAPESP's process: 14/07280-1 - Search for genetic markers of risk, progression and response to treatment
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants
FAPESP's process: 11/00030-1 - Association study of endocannabinoid system and schizophrenia
Grantee:Síntia Iole Nogueira Belangero
Support type: Regular Research Grants