DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis

Author(s):Show less -

Belangero, Sintia Iole ^{[1, 2]} ; Ota, Vanessa Kiyomi ^[1] ; Gadelha, Ary ^{[3, 2]} ; Berberian, Arthur Almeida ^{[3, 2]} ; de Assuncao-Leme, Idaiane Batista ^{[3, 2]} ; Noto, Cristiano ^{[3, 2]} ; Christofolini, Denise Maria ^{[1, 4]} ; Bellucco, Fernanda Teixeira ^[1] ; Santoro, Marcos Leite ^{[1, 3, 2]} ; Mazzotti, Diego Robles ^[5] ; Zugman, Andre ^{[3, 2]} ; Melaragno, Maria Isabel ^[1] ; Cardoso Smith, Marilia Arruda ^[1] ; Pellegrino, Renata ^[6] ; Hakonarson, Hakon ^[6] ; Cordeiro, Quirino ^[7] ; Moretti, Patricia Natalia ^{[1, 8]} ; Bressan, Rodrigo Affonseca ^{[3, 2]} ; Mari, Jair de Jesus ^[3] ; Jackowski, Andrea Parolin ^{[3, 2]}

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, LiNC, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo - Brazil

^[4] Human Reprod & Genet Ctr, Dept Collect Hlth, Fac Med ABC, Santo Andre - Brazil

^[5] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 - USA

^[6] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 - USA

^[7] Santa Casa Sch Med Sci, Dept Psiquiatria, Sao Paulo - Brazil

^[8] Univ Brasilia UNB, Fac Med, Brasilia, DF - Brazil

• Document type: Journal article
• Source: PSYCHIATRY RESEARCH; v. 274, p. 391-394, APR 2019.
• Web of Science Citations: 0

Abstract

We investigated the role of DGCR2, a corticogenesis-related gene, on schizophrenia (SZ) and its subphenotypes, including brain morphology. A total of 221 SZ patients, 263 controls and 70 antipsychotic-naive first episode of psychosis (FEP) were genotyped for 17 DGCR2 polymorphisms. While no association between DGCR2 polymorphisms and SZ was found, the missense variant rs2072123 was associated to left rostral anterior cingulate thickness, showing that DGCR2 seems not to be associated directly with the SZ but might be influencing the brain morphology. We also showed a DGCR2 downregulation in SZ patients when compared to controls and FEP. (AU)

• FAPESP's process: 16/04983-7 - Neuroimaging, genomics, transcriptomics and epigenomics: dealing with big data toward an integrative model of mental disorders
• Grantee: Jair de Jesus Mari
• Support Opportunities: Research Grants - eScience and Data Science Program - Regular Program Grants
• FAPESP's process: 17/25016-8 - Investigation of the treatment response of schizophrenia with risperidone: a pharmacogenetics study in a cohort of first episode of psychosis patients
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/08968-6 - Investigation of genetic and epigenetic markers: a translational approach for schizophrenia treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/07280-1 - Search for genetic markers of risk, progression and response to treatment
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/00030-1 - Association study of endocannabinoid system and schizophrenia
• Grantee: Síntia Iole Nogueira Belangero
• Support Opportunities: Regular Research Grants