| Full text | |
| Author(s): |
Lilian Siqueira
[1]
;
Cynthia Guimarães de Paula
[2]
;
Mariana Motisuke
[3]
;
Rubia Figueredo Gouveia
[4]
;
Samira Esteves Afonso Camargo
[5]
;
Noala Vicensoto Moreira Milhan
[6]
;
Eliandra de Sousa Trichês
[7]
Total Authors: 7
|
| Affiliation: | [1] Universidade Federal de São Paulo. Science and Technology Institute. Bioceramics Laboratory - Brasil
[2] Universidade Federal de São Paulo. Science and Technology Institute. Bioceramics Laboratory - Brasil
[3] Universidade Federal de São Paulo. Science and Technology Institute. Bioceramics Laboratory - Brasil
[4] Centro Nacional de Pesquisa em Energia e Materiais. Brazilian Nanotechnology National Laboratory - Brasil
[5] Universidade Estadual Paulista "Júlio de Mesquita Filho". School of Dentistry. Department of Biosciences and Oral Diagnosis - Brasil
[6] Universidade Estadual Paulista "Júlio de Mesquita Filho". School of Dentistry. Department of Biosciences and Oral Diagnosis - Brasil
[7] Universidade Federal de São Paulo. Science and Technology Institute. Bioceramics Laboratory - Brasil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 20, n. 4, p. 973-983, 2017-05-22. |
| Abstract | |
Replacement tissues for tissue engineering can be produced by seeding human cells onto scaffolds. In order to guarantee adequate bio-compatibility, porosity and mechanical resistance for promoting cellular growth, proliferation and differentiation within scaffold structures, it is necessary to investigate and improve materials and processing routes. β-tricalcium phosphate can be considered a very suitable bio-ceramic material for bone therapy because of its biocompatibility, osteo-conductivity and neo-vascularization potential. Alumina is commonly used as a sintering additive. In this study, β-TCP and β-TCP/Al2O3 scaffolds were obtained by gel-casting method. The scaffolds showed high porosity (86-88%) and pore sizes ranging from 200 to 500 µm. Even though alumina did not promote improvement in β-TCP/Al2O3 scaffolds in terms of mechanical performance, they showed great cytocompatibility as there was no cytotoxic and genotoxic effect. Therefore, β-TCP and β-TCP/Al2O3 scaffolds are good candidates for application in tissue engineering. (AU) | |
| FAPESP's process: | 10/00863-0 - Processing and characterization of B-TCP/Al2O3 nanostructured scaffolds for biomedical applications |
| Grantee: | Eliandra de Sousa Trichês |
| Support Opportunities: | Regular Research Grants |