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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Previously undescribed thyroid-specific miRNA sequences in papillary thyroid carcinoma

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Barros-Filho, Mateus Camargo [1, 2] ; Pewarchu, Michelle [2] ; Minatel, Brenda De Carvalho [2] ; Sage, Adam P. [2] ; Marshall, Erin A. [2] ; Martinez, Victor D. [2] ; Rock, Leigha D. [2, 3, 4] ; MacAulay, Gavin [2] ; Kowalski, Luiz Paulo [1] ; Rogatto, Silvia Regina [5] ; Garnis, Cathie [2] ; Lam, Wan L. [2]
Total Authors: 12
[1] AC Camargo Canc Ctr, Int Res Ctr, Sao Paulo - Brazil
[2] British Columbia Canc Res Ctr, Dept Integrat Oncol, Vancouver, BC - Canada
[3] British Columbia Canc Res Ctr, Dept Canc Control Res, Vancouver, BC - Canada
[4] Univ British Columbia, Fac Dent, Vancouver, BC - Canada
[5] Univ Southern Denmark, Vejle Hosp, Inst Reg Hlth Res, Odense - Denmark
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF HUMAN GENETICS; v. 64, n. 5, p. 505-508, MAY 2019.
Web of Science Citations: 2

Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, wherein diagnostic limitations and lack of accurate prognostic factors are important clinical challenges. In this study, we report the discovery of 234 novel miRNAs in non-neoplastic thyroid and PTC samples, obtained from publicly available small RNA sequencing datasets (TCGA and GEO). These sequences were observed to display similar molecular features compared to currently annotated miRNAs. These potentially novel miRNAs presented tissue-specificity and largely decreased expression in PTC compared to nonneoplastic samples. We showed that the disrupted novel miRNAs have diagnostic and prognostic potential, and were associated with BRAF mutation, a frequent alteration related to more aggressive PTC. In conclusion, our results expand the miRNA repertoire in thyroid tissues and highlight the potential biological role and clinical utility of previously unannotated miRNAs. (AU)

FAPESP's process: 15/20748-5 - Diagnostic and prognostic markers useful in the clinical practice for patients with thyroid nodules: validation of previous findings and functional studies
Grantee:Silvia Regina Rogatto
Support type: Regular Research Grants
FAPESP's process: 18/06138-8 - Small non-coding RNA as master regulators in thyroid cancer
Grantee:Mateus de Camargo Barros Filho
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 15/17707-5 - Development of molecular procedures useful for differential diagnosis in thyroid nodules
Grantee:Mateus de Camargo Barros Filho
Support type: Scholarships in Brazil - Post-Doctorate