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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuropsychological and neuroimaging evidences of cerebral dysfunction in stroke-free patients with atrial fibrillation: A review

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Silva, D. S. [1, 2] ; Coan, A. C. [3, 2] ; Avelar, W. M. [1, 2]
Total Authors: 3
[1] Univ Estadual Campinas, Stroke Ctr, Dept Neurol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, BRAINN, Brazilian Inst Neurosci & Neurotechnol, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Neuroimaging Lab, Dept Neurol, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: JOURNAL OF THE NEUROLOGICAL SCIENCES; v. 399, p. 172-181, APR 15 2019.
Web of Science Citations: 2

Atrial fibrillation (AF) is the most common heart arrhythmia, with the highest prevalence in the elderly. AF has been correlated with silent lesions and cognitive impairment, even in the absence of stroke. The cognitive impairment in AF represents a risk of functional decline, morbidity, mortality and high costs, constituting a public health problem due to the increasing prevalence of this arrhythmia. Cognitive analysis of patients with AF without stroke has shown poor performance in executive, memory and learning functions. The greater loss occurs in speed processing and performance of instrumental tasks leading to functional dependence. Neuroimaging studies have shown both structural and functional abnormalities in individuals with AF even in the absence of cognitive impairment. The mechanisms related to cognitive impairment and cerebral abnormalities in the AF are still a matter of discussion in the literature and, therefore, how to stop its progression is unknown. We reviewed the recent evidence about AF and dementia in patients without stroke, with special emphasis to the reported profile of cognitive dysfunction and the neuroimaging evidence of brain abnormalities. (AU)

FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
Grantee:Fernando Cendes
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/00099-7 - EEG-fMRI in the pre-operatory evaluation of patients with focal refractory epilepsies
Grantee:Ana Carolina Coan
Support type: Scholarships in Brazil - Post-Doctorate