| Full text | |
| Author(s): |
de Pinho, Flaviane Alves
[1, 2]
;
Vieira Vendrame, Celia Maria
[1]
;
Lima Maciel, Bruna Leal
[3]
;
Silva, Lucilene dos Santos
[4]
;
Miyashiro, Samantha Ive
[5]
;
Bezerra Jeronimo, Selma Maria
[6, 7, 8]
;
Goto, Hiro
[1, 9]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Sao Paulo - Brazil
[2] Univ Fed Bahia, Dept Anat Patol & Clin, Escola Med Vet & Zootecnia, Salvador, BA - Brazil
[3] Univ Fed Rio Grande do Norte, Dept Nutricao, Ctr Ciencias Saude, Natal, RN - Brazil
[4] Univ Fed Piaui, Setor Patol Anim, Ctr Ciencias Agr, Teresina - Brazil
[5] Univ Sao Paulo, Dept Clin Med, Fac Med Vet & Zootecnia, Sao Paulo - Brazil
[6] Univ Fed Rio Grande do Norte, Dept Bioquim, Ctr Biociencias, Natal, RN - Brazil
[7] Univ Fed Rio Grande do Norte, Inst Trop Med Rio Grande Norte, Natal, RN - Brazil
[8] Natl Inst Sci & Technol Trop Dis, Natal, RN - Brazil
[9] Univ Sao Paulo, Dept Med Prevent, Fac Med, Sao Paulo - Brazil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | American Journal of Tropical Medicine and Hygiene; v. 100, n. 4, p. 808-815, 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
We analyzed the association between insulin-like growth factor-I (IGF-I) and the pathogenesis of anemia during active visceral leishmaniasis (VL). Serum levels of IGF-I, IGF-binding protein 3 (IGFBP3), and cytokines were measured in samples from individuals with active VL and cured VL, asymptomatic Leishmania-infected, and noninfected individuals. Then, we extended our analysis to VL dogs to evaluate hematimetric parameters, bone marrow alterations, and cytokine and IGF-I expression. We identified a positive correlation between lower IGF-I and IGFBP3 levels in active VL patients and lower hemoglobin levels. In infected dogs, there was a positive correlation between lower IGF-I expression in the bone marrow and lower peripheral blood hematocrit and hemoglobin levels. There was no correlation between decreased IGF-I level/expression and any measured cytokine serum levels in either host. The data suggest that low IGF-I expression is associated with pathogenesis of anemia in active VL, primarily in severe cases, by mechanisms other than alterations in cytokine production. (AU) | |
| FAPESP's process: | 10/16257-2 - Pathogenesis of pancytopenia in canine visceral leishmaniasis |
| Grantee: | Flaviane Alves de Pinho |
| Support Opportunities: | Scholarships in Brazil - Doctorate |