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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Investigation of five alpha-hydroxy acids for enamel and dentin etching: Demineralization depth, resin adhesion and dentin enzymatic activity

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Trevelin, Livia Tosi [1, 2] ; Villanueva, Jose [1] ; Zamperini, Camila A. [1] ; Mathew, Mathew T. [1] ; Matos, Adriana Bona [2] ; Bedran-Russo, Ana K. [1]
Total Authors: 6
[1] Univ Illinois, Dept Restorat Dent, Coll Dent, UIC, Chicago, IL 60612 - USA
[2] Univ Sao Paulo, Dept Operat Dent, Coll Dent, UIC, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Dental Materials; v. 35, n. 6, p. 900-908, JUN 2019.
Web of Science Citations: 0

Objectives. Surface conditioning of enamel and dentin is a key step during adhesive restorative procedures and strategies. The aim of this study was to investigate the effectiveness of five alpha-hydroxy-acids (AHAs) as enamel and dentin surface etchants. Methods. Enamel and dentin specimens were prepared from human molars to determine the depth of demineralization by optical profilometry (Delta z), the resin bond strength to enamel and dentin (mu TBS), the micro-permeability of dentin-resin interfaces, and the gelatinolytic activity of dentin matrix induced by AHAs {[}glycolic (GA), lactic (LA), citric (CA), malic (MI) and tartaric (TA)] and controls {[}phosphoric (PA) and maleic (MA)]. All acids were prepared at 35% concentration. Adhesion studies employed Adper Single Bond Plus bonding system. Data were individually processed and analyzed by ANOVA, post-hoc tests and Pearson correlations (alpha = 0.05). Results. AHA exhibited statistically lower depth of demineralization of enamel and dentin (average 4 fold) than controls (p < 0.001). In enamel, MA and PA etching resulted in higher mu TBS than AHA groups (p < 0.001). In dentin, GA, TA, CI and LA etching resulted in statistically similar mu TBS than PA (p < 0.05). The hybrid-layer (HL) thickness and interfacial micro-permeability intensity were statistically lower for AHA groups (p < 0.05). A significant positive correlation was observed between the intensity of micro-permeability and the thickness of HL (p < 0.05). AHA etchants elicited lower dentin enzymatic activity than controls (p < 0.05). Significance. AHAs effectively etched enamel and dentin surfaces. In particular, GA and TA resulted in suitable mu TBS and sealing ability as well as induced less gelatinolytic activity in dentin than PA and MA. (C) 2019 The Academy of Dental Materials. Published by Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 15/12651-1 - Influence of temporal width pulse of Er:YAG laser in dentin morphology, hybrid layer and bond strength
Grantee:Lívia Tosi Trevelin
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/18118-6 - News strategies to prevent adhesive interface degradation
Grantee:Lívia Tosi Trevelin
Support type: Scholarships abroad - Research Internship - Doctorate