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News strategies to prevent adhesive interface degradation

Grant number: 16/18118-6
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): January 16, 2017
Effective date (End): November 15, 2017
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Adriana Bona Matos
Grantee:Lívia Tosi Trevelin
Supervisor abroad: Ana Karina Barbieri Bedran-Russo
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Illinois at Chicago (UIC), United States  
Associated to the scholarship:15/12651-1 - Influence of temporal width pulse of Er:YAG laser in dentin morphology, hybrid layer and bond strength, BP.DR


The in vitro study will investigate new dentin and enamel surfaces etching strategies and surface biomodification/reinforcement for effective placement of adhesive restorations, shifting into biomimetic approaches to restore the remaining tissue structure and evaluated over time. In the first phase, sixty-four human molar will be prepared and etching with glycolic acid or lactic acid (the concentration and timeframe will be optimized in pilot studies) and will be evaluated by different methods: scanning electron microscopy, zimography analysis, nanoindentations, microtensile bond strength and confocal microscopy. After this step, the conditioning agent that will have the best performance will be used in the second phase, in which sixty-four human molars will be prepared and etching according with phase I and after, two new primers will be prepared by bioactive compounds within the rich plant sources of proantocianidins (PACs). Utilizing a phytochemical designer concept, we will use enriched mixtures of PACs from cinnamon and pine and will apply in dentin (the PACs-rich concentration and timeframe will be optimized in pilot studies) surface after etching procedure. The ability of reinforce the stability of resin dentin will be evaluated by in situ zymography, microtensile bond strength and confocal microscopy after 24 hours and axial cyclic loading (50 N). Quantitative data obtained will be analyzed statistically (p <0.05) and qualitative will be described in comparison.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TREVELIN, LIVIA TOSI; ALANIA, YVETTE; MATHEW, MATHEW; PHANSALKAR, RASIKA; CHEN, SHAO-NONG; PAULI, GUIDO F.; BEDRAN-RUSSO, ANA K. Effect of dentin biomodification delivered by experimental acidic and neutral primers on resin adhesion. Journal of Dentistry, v. 99, AUG 2020. Web of Science Citations: 0.
TREVELIN, LIVIA TOSI; VILLANUEVA, JOSE; ZAMPERINI, CAMILA A.; MATHEW, MATHEW T.; MATOS, ADRIANA BONA; BEDRAN-RUSSO, ANA K. Investigation of five alpha-hydroxy acids for enamel and dentin etching: Demineralization depth, resin adhesion and dentin enzymatic activity. Dental Materials, v. 35, n. 6, p. 900-908, JUN 2019. Web of Science Citations: 0.

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