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Influence of chitosan on the biomodification of eroded dentin: clinical and photographic longitudinal analysis of restorations

Grant number: 17/25757-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2018
Effective date (End): November 30, 2019
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Silmara Aparecida Milori Corona
Grantee:José Caetano de Souza
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The application of adhesive systems on eroded dentine may represent a challenge to restorative therapy, since the modifications that occur in the dentin surface, caused by the erosive process, compromise the introduction of adhesive in the organic dentin matrix, which decreases the quality and longevity of the restorations. The clinical application of biomodifying substances, such as chitosan, can improve the mechanical resistance of collagen, increasing its resistance to the degradation of collagen fibrils, used as support for the establishment of adhesive interfaces. Therefore, it is relevant to evaluate the influence of biomodification of eroded dentin by a biopolymer (chitosan), in order to improve its structural integrity and restorations. This study aims to evaluate the influence of biomodification with chitosan on erosion lesions by means of longitudinal and photographic analysis of the restorations performed. The sample will consist of 20 patients between 18 and 60 years of age who present non - carious erosion lesions of shallow or medium depth, located on the palatal or lingual surface of at least two homologous teeth (minimum - 40 teeth). The teeth of each patient will be randomly distributed into two groups according to the dentine surface treatment: 1) without biomodification (control) and 2) 2.5% chitosan. Conditioning will be performed with 35% phosphoric acid and then the cavity will be washed. For the group that will receive the biomodification with chitosan, chitosan will be applied at 2.5% for 60 seconds, and the surface will be dried with absorbent paper. The specimens will then be restored with adhesive (Adper Single Bond 2 - 3M) and composite resin (Z250 - 3M). For clinical and photographic analysis of the restorations, three calibrated and experienced professionals will use the modified United States Public Health Service (USPHS) criteria within 7 days (after polishing) and 6 months of restorations. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA, JOSE CAETANO; TEDESCO, ANTONIO CLAUDIO; UNTEN TAKAHASHI, LUANDRA APARECIDA; CURYLOFO-ZOTTI, FABIANA ALMEIDA; SOUZA-GABRIEL, ALINE EVANGELISTA; MILORI CORONA, SILMARA APARECIDA. Influence of nanoparticulated chitosan on the biomodification of eroded dentin: clinical and photographic longitudinal analysis of restorations. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 32, n. 1, . (17/11582-1, 17/25757-8)

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