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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acute effects of somatomammotropin hormones on neuronal components of the hypothalamic-pituitary-gonadal axis

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Silveira, Marina A. [1] ; Zampieri, Thais T. [1] ; Furigo, Isadora C. [2] ; Abdulkader, Fernando [2] ; Donato, Jr., Jose [2] ; Frazao, Renata [1]
Total Authors: 6
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brain Research; v. 1714, p. 210-217, JUL 1 2019.
Web of Science Citations: 3

Growth hormone (GH) and prolactin (PRL) are known as pleiotropic hormones. Accordingly, the distribution of their receptors comprises several organs and tissues, including the central nervous system. The appropriate secretion of both hormones is essential for sexual maturation and maintenance of reproductive functions, while defects in their secretion affect puberty onset and can cause infertility. Conversely, GH therapy at a prepubertal age may accelerate puberty. On the other hand, hyperprolactinemia is a frequent cause of infertility. While the action of PRL in some central components of the Hypothalamic-Pituitary-Gonadal (HPG) axis, such as the kisspeptin neurons, has been well documented, the possible effects of GH in the hypothalamus are still elusive. Thus, the present study was designed to investigate whether somatomammotropin hormones are able to modulate the activity of critical neuronal components of the HPG axis, including kisspeptin neurons and cells of the ventral premammillary nucleus (PMv). Our results revealed that GH effects in kisspeptin neurons of the anteroventral periventricular and rostral periventricular nuclei or in PMv neurons relies predominantly on the recruitment of the signal transducer and activator of transcription 5 (STAT5) rather than through acute changes in resting membrane potential. Importantly, kisspeptin neurons located at the arcuate nucleus were not directly responsive to GH. Additionally, our findings further identified PMv neurons as potential targets of PRL, since PRL induces the phosphorylation of STAT5 and depolarizes PMv neurons. Combined, our data provide evidence that GH and PRL may affect the HPG axis via specific hypothalamic neurons. (AU)

FAPESP's process: 13/07908-8 - Precocious puberty in childhood obesity: possible mechanisms and influence of leptin
Grantee:Renata Frazão
Support type: Regular Research Grants
FAPESP's process: 15/20198-5 - Role of Leptin in puberal neuromodulation
Grantee:Thais Tessari Zampieri
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/02983-2 - The role of growth hormone in the brain: relevance for neural functions and in disease
Grantee:Jose Donato Junior
Support type: Research Projects - Thematic Grants
FAPESP's process: 16/09679-4 - Central effects of growth hormone on energetic metabolism and glicemic control
Grantee:Isadora Clivatti Furigo
Support type: Scholarships in Brazil - Post-Doctorate