Insulin and Autophagy in Neurodegeneration

Author(s)

de Mollo, Natalia Prudente ^[1] ; Orellana, Ana Maria ^[2] ; Mazucanti, Caio Henrique ^[2] ; Lima, Geovanni de Morals ^[1] ; Scavone, Cristoforo ^[2] ; Kawamoto, Elise Mitiko ^[1]

Affiliation

^[1] Univ Sao Paulo, Lab Mol & Funct Neurobiol, Dept Pharmacol, Inst Biomed Sci, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Lab Mol Neuropharmacol, Dept Pharmacol, Inst Biomed Sci, Sao Paulo - Brazil

• Document type: Review article
• Source: FRONTIERS IN NEUROSCIENCE; v. 13, MAY 22 2019.
• Web of Science Citations: 0

Abstract

Crosstalk in the pathophysiological processes underpinning metabolic diseases and neurodegenerative disorders have been the subject of extensive investigation, in which insulin signaling and autophagy impairment demonstrate to be a common factor in both conditions. Although it is still somewhat conflicting, pharmacological and genetic strategies that regulate these pathways may be a promising approach for aggregate protein clearancing and consequently the delaying of onset or progression of the disease. However, as the response due to this modulation seems to be time-dependent, finding the right regulation of autophagy may be a potential target for drug development for neurodegenerative diseases. In this way, this review focuses on the role of insulin signaling/resistance and autophagy in some neurodegenerative diseases, discussing pharmacological and non-pharmacological interventions in these diseases. (AU)

• FAPESP's process: 16/22996-9 - Evaluation of physical exercise effects on cognition of neuronal-PTEN deleted animals
• Grantee: Elisa Mitiko Kawamoto Iwashe
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/07427-8 - Aging and neuroprotection: effects of Klotho protein in energetic metabolism, Na,K-ATPase signaling and adaptative response in central nervous system
• Grantee: Cristoforo Scavone
• Support Opportunities: Research Projects - Thematic Grants