Novel polymeric dressing to the treatment of infected chronic wound

Author(s):Show less -

Garms, Bruna Cambraia ^[1] ; Borges, Felipe Azevedo ^[1] ; de Barros, Natan Roberto ^[1] ; Marcelino, Monica Yonashiro ^[2] ; Leite, Marcel Nani ^[3] ; Del Arco, Marina Constante ^[4] ; de Souza Salvador, Sergio Luiz ^[4] ; Pegorin, Giovana Sant'Ana ^[2] ; Mustafe Oliveira, Kassandra Sussi ^[5] ; Cipriani Frade, Marco Andrey ^[3] ; Herculano, Rondinelli Donizetti ^[2]

Affiliation

^[1] Sao Paulo State Univ UNESP, Inst Chem, Sao Paulo - Brazil

^[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Sao Paulo - Brazil

^[3] Sao Paulo Univ USP, Sch Med, Sao Paulo - Brazil

^[4] Sao Paulo Univ USP, Sch Pharmaceut Sci, Sao Paulo - Brazil

^[5] Sao Paulo State Univ UNESP, Fac Agr Sci, Sao Paulo - Brazil

• Document type: Journal article
• Source: Applied Microbiology and Biotechnology; v. 103, n. 12, p. 4767-4778, JUN 2019.
• Web of Science Citations: 0

Abstract

Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment. (AU)

• FAPESP's process: 14/17526-8 - Development of a novel system employing natural rubber latex as releasing of vegetable extracts incorporated with nanoparticles: physical chemical and biological characterization
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants