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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Panicolytic-like effect of mu(1)-opioid receptor blockade in the inferior colliculus of prey threatened by Crotalus durissus terrificus pit vipers

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Author(s):
Calvo, Fabricio [1, 2, 3, 4] ; Almada, Rafael Carvalho [2, 3, 5] ; dos Anjos-Garcia, Tayllon [2, 3, 6] ; Falconi-Sobrinho, Luiz Luciano [2, 3, 5, 6] ; Paschoalin-Maurin, Tatiana [2, 3, 5] ; Bazaglia-de-Sousa, Guilherme [2, 3, 5, 6] ; Medeiros, Priscila [2, 3, 5] ; da Silva, Juliana Almeida [2, 3, 5, 6] ; Lobao-Soares, Bruno [7, 2, 3, 5] ; Coimbra, Norberto Cysne [2, 3, 5, 6]
Total Authors: 10
Affiliation:
[1] Sao Lucas Coll, Dept Pharmacol, Porto Velho, RO - Brazil
[2] Univ Sao Paulo FMRP USP, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo FMRP USP, Ophidiarium LNN FMRP USP INeC, Ribeirao Preto, SP - Brazil
[4] Aparicio Carvalho Integrat Coll FIMCA, Porto Velho, RO - Portugal
[5] Behav Neurosci Inst INeC, Ribeirao Preto, SP - Brazil
[6] Univ Sao Paulo FMRP USP, NAP USP Neurobiol Emot Res Ctr NuPNE, Ribeirao Preto, SP - Brazil
[7] Fed Univ Rio Grande Norte UFRN, Dept Biophys & Pharmacol, Natal, RN - Brazil
Total Affiliations: 7
Document type: Journal article
Source: JOURNAL OF PSYCHOPHARMACOLOGY; v. 33, n. 5, p. 577-588, MAY 2019.
Web of Science Citations: 2
Abstract

Background: The endogenous opioid peptide system has been implicated in the neural modulation of fear and anxiety organised by the dorsal midbrain. Furthermore, previous results indicate a fundamental role played by inferior colliculus (IC) opioid mechanisms during the expression of defensive behaviours, but the involvement of the IC mu(1)-opioid receptor in the modulation of anxiety- and panic attack-related behaviours remains unclear. Using a prey-versus-snake confrontation paradigm, we sought to investigate the effects of mu(1)-opioid receptor blockade in the IC on the defensive behaviour displayed by rats in a dangerous situation. Methods: Specific pathogen-free Wistar rats were treated with microinjection of the selective mu(1)-opioid receptor antagonist naloxonazine into the IC at different concentrations (1.0, 3.0 and 5.0 mu g/0.2 mu L) and then confronted with rattlesnakes (Crotalus durissus terrificus). The defensive behavioural repertoire, such as defensive attention, flat back approach (FBA), startle, defensive immobility, escape or active avoidance, displayed by rats either during the confrontations with wild snakes or during re-exposure to the experimental context without the predator was analysed. Results: The blockade of mu(1)-opioid receptors in the IC decreased the expression of both anxiety-related behaviours (defensive attention, FBA) and panic attack-related responses (startle, defensive immobility and escape) during the confrontation with rattlesnakes. A significant decrease in defensive attention was also recorded during re-exposure of the prey to the experimental apparatus context without the predator. Conclusion: Taken together, these results suggest that a decrease in mu(1-)opioid receptor signalling activity within the IC modulates anxiety- and panic attack-related behaviours in dangerous environments. (AU)

FAPESP's process: 09/02458-9 - Neuropharmacological study of the interaction between cannabinoid and opioid circuits of the substantia nigra, pars reticulata, on the activity of the nigrotectal GABAergic pathways, and of its role in the modulation of the innate fear-induced analgesia
Grantee:Juliana Almeida da Silva
Support type: Scholarships in Brazil - Master
FAPESP's process: 07/01174-1 - Study of the Involvement of opioid-, serotonergic- and noradrenergic-mechanisms of the pain endogenous inhibitory system in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the merdial hypothalamus
Grantee:Norberto Cysne Coimbra
Support type: Regular Research Grants
FAPESP's process: 12/22681-7 - Involvement of Opioid and Endocanabinoid Receptors of the Substantia Nigra, Pars Reticulata, in the Modulation of the Activity of Nigro-Tectal GABAergic Pathways during the Organization of Defensive Behaviour of Mice Confronted with Venomous Snakes
Grantee:Rafael Carvalho Almada
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/11855-8 - Study of corpus striatum and ventral mesencephalon endocanabinoid influence on neostriato-nigro-tectal GABAergic pathways during panic reactions of rodents threatened by venomous snakes
Grantee:Norberto Cysne Coimbra
Support type: Regular Research Grants
FAPESP's process: 13/10984-8 - Influence of the anterior cingulate cortex and involvement of hypothalamic NMDA and AMPA/kainite glutamatergic receptorsin the organization of the defensive behaviorand innate fear-induced antinociception elaborated by posterior hypothalamus
Grantee:Luiz Luciano Falconi Sobrinho
Support type: Scholarships in Brazil - Master
FAPESP's process: 12/03798-0 - Involvement of opioid and endocanabinoid receptors of the substantia nigra on the activity of Nigro-Tectal GABAergic pathways during defensive behaviour elicited by rodents confronted with venomous snakes
Grantee:Norberto Cysne Coimbra
Support type: Regular Research Grants
FAPESP's process: 12/25167-2 - Role of glutamatergic, endocannabinoid and endovaniloid systems of medial pre-frontal cortex in neurophatic pain model: Investigation of panic and chronic pain comorbidity
Grantee:Priscila de Medeiros
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/10313-1 - Study of nigro-tectal GABAergic pathways activity during the elaboration of defensive behaviour: role of endocannabinoid mediated neuromodulation in the caudatum putamen of the GABAergic disinhibitory neostriatum-nigral inhibitory nigro-collicular pathways
Grantee:Juliana Almeida da Silva
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/13560-5 - Effect of deep brain stimulation and cannabidiol treatment in the subthalamic nucleus on the motors and non-Motors symptoms in the experimental model of Parkinson Disease
Grantee:Priscila de Medeiros
Support type: Scholarships in Brazil - Post-Doctorate