Associations between children's family environment, spontaneous brain oscillations, and emotional and behavioral problems

Author(s):Show less -

Sato, Joao Ricardo ^{[1, 2, 3, 4, 5]} ; Biazoli Jr, Claudinei Eduardo ; Salum, Giovanni Abrahao ^{[6, 7, 4]} ; Gadelha, Ary ^{[2, 4]} ; Crossley, Nicolas ^[8] ; Vieira, Gilson ^{[9, 10]} ; Zugman, Andre ^{[2, 4]} ; Picon, Felipe Almeida ^{[6, 7, 4]} ; Pan, Pedro Mario ^{[2, 4]} ; Hoexter, Marcelo Queiroz ^{[11, 2, 4]} ; Amaro Jr, Edson ; Anes, Mauricio ^{[6, 7, 4]} ; Moura, Luciana Monteiro ^{[2, 4]} ; Gomes Del'Aquilla, Marco Antonio ^{[2, 4]} ; Mcguire, Philip ^[8] ; Rohdez, Luis Augusto ^{[6, 7, 4]} ; Miguel, Euripedes Constantino ^{[11, 4]} ; Bressan, Rodrigo Affonseca ^{[2, 4]} ; Jackowski, Andrea Parolin ^{[2, 4]}

Affiliation:Show less -

^[1] Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci LiNC, Sao Paulo - Brazil

^[3] Univ Fed Abc, Ctr Math Computat & Cognit, Av Estados 5001, BR-09210580 Santo Andre, SP - Brazil

^[4] Natl Inst Dev Psychiat Children & Adolescents CNP, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Sch Med, Inst Radiol InRad, Sao Paulo - Brazil

^[6] Univ Fed Rio Grande do Sul, Dept Psychiat, Porto Alegre, RS - Brazil

^[7] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Porto Alegre, RS - Brazil

^[8] Kings Coll London, Inst Psychiat, London - England

^[9] Univ Sao Paulo, Inst Math & Stat, Bioinformat Program, Sao Paulo - Brazil

^[10] Biazoli Jr, Jr., Claudinei Eduardo, Univ Sao Paulo, Sch Med, Dept Radiol, Sao Paulo - Brazil

^[11] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo - Brazil

• Document type: Journal article
• Source: EUROPEAN CHILD & ADOLESCENT PSYCHIATRY; v. 28, n. 6, p. 835-845, JUN 2019.
• Web of Science Citations: 0

Abstract

The family environment in childhood has a strong effect on mental health outcomes throughout life. This effect is thought to depend at least in part on modifications of neurodevelopment trajectories. In this exploratory study, we sought to investigate whether a feasible resting-state fMRI metric of local spontaneous oscillatory neural activity, the fractional amplitude of low-frequency fluctuations (fALFF), is associated with the levels of children's family coherence and conflict. Moreover, we sought to further explore whether spontaneous activity in the brain areas influenced by family environment would also be associated with a mental health outcome, namely the incidence of behavioral and emotional problems. Resting-state fMRI data from 655 children and adolescents (6-15years old) were examined. The quality of the family environment was found to be positively correlated with fALFF in the left temporal pole and negatively correlated with fALFF in the right orbitofrontal cortex. Remarkably, increased fALFF in the temporal pole was associated with a lower incidence of behavioral and emotional problems, whereas increased fALFF in the orbitofrontal cortex was correlated with a higher incidence. (AU)

• FAPESP's process: 13/10498-6 - Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders
• Grantee: João Ricardo Sato
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/08531-5 - High risk cohort study for psychiatric disorders in childhood: 3-year follow-up neuroimaging study
• Grantee: Andrea Parolin Jackowski
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/00506-1 - Time series, wavelets and functional data analysis
• Grantee: Pedro Alberto Morettin
• Support Opportunities: Research Projects - Thematic Grants