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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative study on the degradation of cephalexin by four electrochemical advanced oxidation processes: Evolution of oxidation intermediates and antimicrobial activity

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Author(s):
Antonin, Vanessa S. [1] ; Aquino, Jose M. [1] ; Silva, Bianca F. [2] ; Silva, Adilson J. [3] ; Rocha-Filho, Romeu C. [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, CP 676, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Estadual Paulista, Dept Quim Analit, Inst Quim Araraquara, BR-14800900 Araraquara, SP - Brazil
[3] Univ Fed Sao Carlos, Dept Engn Quim, CP 676, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: CHEMICAL ENGINEERING JOURNAL; v. 372, p. 1104-1112, SEP 15 2019.
Web of Science Citations: 0
Abstract

The degradation of the beta-lactam antibiotic cephalexin (CEX) was carried out by the following electrochemical advanced oxidation processes (EAOPs): anodic oxidation (AO), Fered-Fenton (EF-Fered), photoassisted anodic oxidation (PAO), and photoassisted Fered-Fenton (PEF-Fered). All experiments were done in a flow reactor incorporating a boron-doped diamond anode, at a low current density; for the PAO and PEF-Fered processes, the solution was irradiated with UVA light. The initial removal of CEX was attained by all EAOPs, but it was much faster by the Fenton-based processes, which thus presented higher initial rates of TOC removal. However, the coupling of the electrolytic and UVA photolytic processes enhanced the mineralization process; as a consequence, significantly greater TOC removals were attained by the PEF-Fered and PAO processes. From the initial oxidation intermediates detected by LC-MS/MS for the PEF-Fered and AO processes, it could be concluded that addition reactions involving the electrophilic HO center dot radicals occurred preferentially in the beta-lactam ring; however, due to the higher availability of HO center dot radicals, the Fenton-based process led to a faster rupture of that ring. Thus, the antibacterial activity of the treated CEX solution against Escherichia coli was completely terminated within less than 1 h of treatment by the PEF-Fered process, compared to 8 h by the AO process. The PEF-Fered and PAO processes yielded enhanced degradation performances despite mere use of UVA light. (AU)

FAPESP's process: 18/10805-0 - 69th Annual Meeting of the International Society of Electrochemistry
Grantee:Romeu Cardozo Rocha Filho
Support Opportunities: Research Grants - Meeting - Abroad