Tailoring the synthesis of tantalum-based thin films for biomedical application: Characterization and biological response

Author(s)

Beline, Thamara ^{[1, 2]} ; da Silva, Jose H. D. ^[3] ; Matos, Adaias O. ^{[1, 2]} ; Azevedo Neto, Nilton F. ^[3] ; de Almeida, Amanda B. ^[1] ; Nociti Junior, Francisco H. ^[1] ; Leite, Douglas M. G. ^[4] ; Rangel, Elidiane Cipriano ^[5] ; Barao, Valentim A. R. ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Prosthodont & Periodontol, UNICAMP, Av Limeira 901, BR-13414903 Piracicaba, SP - Brazil

^[2] Inst Biomat Tribocorros & Nanomed IBTN, Rio De Janeiro, RJ - Brazil

^[3] Sao Paulo State Univ UNESP, Sch Sci, Dept Phys, Av Eng Luis Edmundo C Coube 14-01, BR-17033360 Bauru, SP - Brazil

^[4] Technol Inst Aeronaut ITA, Plasma & Proc Lab, Pca Marechal Eduardo Gomes 50, BR-12228900 Sao Jose Dos Campos, SP - Brazil

^[5] Sao Paulo State Univ UNESP, Inst Sci & Technol, Lab Technol Plasmas, Av Tres de Marco 511, BR-18087180 Sorocaba, SP - Brazil

• Document type: Journal article
• Source: Materials Science & Engineering C-Materials for Biological Applications; v. 101, p. 111-119, AUG 2019.
• Web of Science Citations: 0

Abstract

The aim of this study was to tailor the deposition parameters of magnetron sputtering to synthetize tantalum oxide (TaxOy) films onto commercially pure titanium (cpTi) surface. The structural and optical properties, morphology, roughness, elemental chemical composition and surface energy were assessed. The impact of TaxOy films on initial Streptococcus sanguinis adhesion was investigated. The morphology and spreading of pre-osteoblastic (MC3T3-E1) cells on a crystalline tantalum oxide film were evaluated. TaxOy films with estimated thickness of 600 nm and different structures (amorphous or crystalline) were produced depending on the various oxygen flow rates and parameters used. X-ray diffraction analysis revealed that the 8 O-2 sccm (600 degrees C/400 W) group showed crystallization corresponding to the beta-TaxO5 phase. Optical analysis showed that the 4 O-2 sccm (200 degrees C 300 W) to 8 O-2 sccm (600 degrees C 300 W) groups and 10 O-2 sccm (200 degrees C 300 W) group presented regular and large-amplitude interference oscillations, suggesting high optical homogeneity of the films. The crystalline beta-TaxO5 coating showed higher roughness and surface energy values than the other groups (P < .05) and was biocompatible. Compared with cpTi, the amorphous and crystalline tantalum oxide films did not increase bacterial adhesion (P > .05). By tailoring the deposition parameters, we synthetized a crystalline beta-TaxO5 coating that improved titanium surface properties and positively affected cell spreading and morphology, making it a promising surface treatment for titanium-based implants. (AU)

• FAPESP's process: 16/11470-6 - Magnetron sputtering deposition of tantalum oxide (Ta2O5) films onto titanium surface for biomedical applications: electrochemical behavior, biocompatibility and microbiologic analysis
• Grantee: Valentim Adelino Ricardo Barão
• Support type: Regular Research Grants
• FAPESP's process: 16/07269-3 - Magnetron sputtering deposition of tantalum oxide (Ta2O5) films onto titanium surface for biomedical applications: electrochemical behavior, biocompatibility and microbiologic analysis
• Grantee: Thamara Beline
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/18916-2 - Optimization of the Growth Process of Co3O4 Films for Photovoltaic and Photocatalytic Applications
• Grantee: Jose Humberto Dias da Silva
• Support type: Regular Research Grants