Persistent Poor Metabolic Profile in Postmenopausal Women With Ovarian Hyperandrogenism After Testosterone Level Normalization

Author(s)

Rocha, Thais ^[1] ; Crespo, Raiane P. ^[1] ; Yance, Viviane V. R. ^[1] ; Hayashida, Sylvia A. ^[2] ; Baracat, Edmund C. ^[2] ; Carvalho, Filomena ^[3] ; Domenice, Sorahia ^[1] ; Mendonca, Berenice B. ^[1] ; Gomes, Larissa G. ^[1]

Affiliation

^[1] Univ Sao Paulo, Hosp Clin, Fac Med, Unidade Endocrinol Desenvolvimento, Disciplina Endocrinol & Metabol, Lab Hormonios & G, BR-0540100 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Hosp Clin, Dept Obstetricia & Ginecol, Fac Med, Disciplina Ginecol, BR-0540100 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Disciplina Patol, BR-01246903 Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF THE ENDOCRINE SOCIETY; v. 3, n. 5, p. 1087-1096, MAY 2019.
• Web of Science Citations: 0

Abstract

Context: Data on prevalence of metabolic risk factors in hyperandrogenic postmenopausal women are limited. Also, the correlation between metabolic disorders and androgen excess in this scenario is poorly understood. Objectives: We aimed to assess the prevalence of obesity, hypertension, type 2 diabetes (T2D), and dyslipidemia (DLP) in postmenopausal women with hyperandrogenism of ovarian origin before and after surgical normalization of testosterone (T) levels, as well as the impact of androgen normalization on body mass index (BMI), glucose, and lipid metabolism. Design: Retrospective study. Setting: Tertiary health center. Participants: Twenty-four Brazilian women with postmenopausal hyperandrogenism who underwent bilateral oophorectomy between 2004 and 2014 and had histologically confirmed virilizing ovarian tumor (VOT) or ovarian hyperthecosis (OH) and T-level normalization after surgery were selected. Main Outcome Measures: FSH, LH, total and calculated free T, BMI, fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) serum levels were accessed before (n = 24) and 24 months after (n 5 19) bilateral oophorectomy. Results: At baseline, the overall prevalence rates of obesity, T2D, DLP, and hypertension were 58.3%, 83.3%, 66.7%, and 87.5%, respectively. No significant difference in prevalence was found between patients with OH and VOTs. At follow-up, FSH, LH, and total and free T levels had returned to menopausal physiologic levels, but mean BMI and mean FPG, HbA1c, LDL-C, HDL-C, and TG levels did not differ from baseline. Conclusions: Postmenopausal hyperandrogenism is associated with adverse metabolic risk. Longterm normalization of testosterone levels did not improve BMI, glucose, or lipid metabolism. Copyright (C) 2019 Endocrine Society (AU)

• FAPESP's process: 15/17350-0 - Molecular analysis of Candidates Genes for Polycystic Ovary Syndrome Through New Generation Sequencing
• Grantee: Larissa Garcia Gomes
• Support Opportunities: Regular Research Grants