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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Development and characterization of membranes derived from SF/GLY/58S hybrid xerogels for the release of inorganic ions as an osteogenic stimulus for bone regeneration

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Author(s):
Lopes, J. H. [1, 2] ; Franca, C. G. [1] ; Beppu, M. M. [1]
Total Authors: 3
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Sch Chem Engn FEQ, Lab Engn & Prod Chem LEQUIP, Dept Mat Engn & Biopr, BR-13083852 Campinas, SP - Brazil
[2] Aeronaut Inst Technol ITA, Div Fundamental Sci IEF, Dept Chem, Praca Marechal Eduardo Gomes 50, BR-12228900 Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: EUROPEAN POLYMER JOURNAL; v. 116, p. 425-437, JUL 2019.
Web of Science Citations: 0
Abstract

The ternary membrane-forming system based on the silk fibroin (SF), glycerol (GLY) and sol-gel precursor of 58S bioactive glass (BG) was studied for the preparation of novel and multifunctional hybrid membranes. The morphology of membranes was observed by scanning electron microscopy (SEM) and spectral imaging, by X-ray mapping technique, were performed in order to investigate the chemical homogeneity of elements. The results show that there is a critical limit for the concentration of GLY and BG for formation of flexible membranes and without a phase separation. XRD and FTIR data showed that the GLY and BG in the silk matrix modifies the short- and intermediate-range order resulting in changes in the silk conformation, i.e., SF molecules are gradually transformed from random coils toward more stable structures - Silk I and Silk II (beta-sheets). The solubility study showed that the hybrid membranes have an excellent chemical stability, confirming that the incorporation of inorganic species in the matrix allowed the preparation of novel well-controlled water-soluble membranes. The release profiles of Ca, P and Si confirmed ability of hybrid membranes to deliver controlled inorganic species, which in critical concentration, control the gene expression of osteoblasts and influences cell metabolism and function. (AU)

FAPESP's process: 10/05394-9 - Bioglasses derived from 45S5: effects of Nb2O5 or surface modification with Ca2+ on the glass structure and bioactivity
Grantee:João Henrique Lopes
Support Opportunities: Scholarships in Brazil - Doctorate