Algicidal effect of blue light on pathogenic Prototheca species

Author(s)

dos Anjos, Carolina ^[1] ; Sellera, Fabio Parra ^[1] ; Gargano, Ronaldo Gomes ^[1] ; Lincopan, Nikon ^{[2, 3]} ; Pogliani, Fabio Celidonio ^[1] ; Ribeiro, Marcio Garcia ^[4] ; Jagielski, Tomasz ^[5] ; Sabino, Caetano Padial ^{[3, 6]}

Affiliation

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Internal Med, Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, SP - Brazil

^[4] Sao Paulo State Univ UNESP, Dept Vet Hyg & Publ Hlth, Botucatu, SP - Brazil

^[5] Univ Warsaw, Fac Biol, Inst Microbiol, Dept Appl Microbiol, Warsaw - Poland

^[6] Sci & Commercial LTD, BioLambda, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 26, p. 210-213, JUN 2019.
• Web of Science Citations: 1

Abstract

Prototheca spp. are pathogenic algae with important zoonotic potential. Most importantly, these algae often infect dairy cattle. Since there is no effective therapy against the algae, the standard recommendation is the disposal or culling of infected cows to avoid outbreaks. This study investigated the ability of blue light to inactivate pathogenic Prototheca species. Blue LED light (lambda = 410 nm) was used to inactivate in vitro suspensions of P. zopfii genotypes 1 and 2, and P. blaschkeae. Our results showed that blue light irradiation induced a strain specific dose-dependent algicidal effect against all tested strains. P. zopfii genotype 1, was more sensitive than genotype 2 and P. blaschkeae was the most tolerant. Even though we observed different inactivation kinetics, all strains presented significant photoinactivation levels within feasible procedure periods. Therefore, we conclude that blue light irradiation offers promising potential for the development of novel technologies that control contaminations and infections caused by Prototheca spp. (AU)

• FAPESP's process: 16/25095-2 - BACTERIAL PHOTOINACTIVATION OF MASTITIS PATHOGENS BY BLUE LIGHT: MECHANISMS OF ACTION AND CELL SECURITY - PRE-CLINICAL STUDY
• Grantee: Carolina dos Anjos
• Support Opportunities: Scholarships in Brazil - Doctorate