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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exploring the Role of Staphylococcus Aureus Toxins in Atopic Dermatitis

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Yamada Yoshikawa, Fabio Seiti [1] ; de Lima, Josenilson Feitosa [1] ; Sato, Maria Notomi [1] ; Leuzzi Ramos, Yasmin Alefe [1] ; Aoki, Valeria [1] ; Orfali, Raquel Leao [1]
Total Authors: 6
[1] Univ Sao Paulo, Sch Med, Dept Dermatol, Lab Dermatol & Immunodeficiencies LIM 56, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: TOXINS; v. 11, n. 6 JUN 2019.
Web of Science Citations: 1

Atopic dermatitis (AD) is a chronic and inflammatory skin disease with intense pruritus and xerosis. AD pathogenesis is multifactorial, involving genetic, environmental, and immunological factors, including the participation of Staphylococcus aureus. This bacterium colonizes up to 30-100% of AD skin and its virulence factors are responsible for its pathogenicity and antimicrobial survival. This is a concise review of S. aureus superantigen-activated signaling pathways, highlighting their involvement in AD pathogenesis, with an emphasis on skin barrier disruption, innate and adaptive immunity dysfunction, and microbiome alterations. A better understanding of the combined mechanisms of AD pathogenesis may enhance the development of future targeted therapies for this complex disease. (AU)

FAPESP's process: 18/23211-0 - Evaluation of inflammasome profile in cutaneous lesions of adults with atopic dermatitis
Grantee:Valeria Aoki
Support Opportunities: Regular Research Grants
FAPESP's process: 16/24161-1 - Protemic characterization of exosomes from plasma and dermal fibroblasts in adults with atopic dermatitis
Grantee:Raquel Leão Orfali
Support Opportunities: Regular Research Grants