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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Distribution, Function and Regulation of Type 6 Secretion Systems of Xanthomonadales

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Author(s):
Bayer-Santos, Ethel [1] ; Ceseti, Lucas de Moraes [2] ; Farah, Chuck Shaker [3] ; Alvarez-Martinez, Cristina Elisa [2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Genet Evolucao Microbiol & Imunol, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Review article
Source: FRONTIERS IN MICROBIOLOGY; v. 10, JUL 17 2019.
Web of Science Citations: 0
Abstract

Members of the Xanthomonadales order include several plant pathogens of significant economic and agricultural impact, such as Xanthomonas spp. Type 6 secretion systems (T6SSs) are contractile nanomachines used by many bacterial species to inject protein effectors into target prokaryotic and eukaryotic cells and provide a competitive advantage for bacteria in different environments. Effectors with antibacterial properties include peptidoglycan hydrolases, lipases and phospholipases that break down structural components of the cell envelope, promoting target-cell lysis; and RNases, DNAses, and NADases that affect target-cell metabolism, arresting growth. Effectors with anti-eukaryotic properties are functionally more diverse. The T6SS of Xanthomonas citri is the only example experimentally characterized so far within the Xanthomonadales order and displays anti-eukaryotic function by providing resistance to predation by amoeba. This T6SS is regulated at the transcriptional level by a signaling cascade involving a Ser/Thr kinase and an extracytoplasmic function (ECF) sigma factor. In this review, we performed in silico analyses of 35 genomes of Xanthomonadales and showed that T6SSs are widely distributed and phylogenetically classified into three major groups. In silico predictions identified a series of proteins with known toxic domains as putative T6SS effectors, suggesting that the T6SSs of Xanthomonadales display both anti-prokaryotic and anti-eukaryotic properties depending on the phylogenetic group and bacterial species. (AU)

FAPESP's process: 18/04553-8 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells
Grantee:Ethel Bayer Santos
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 17/17303-7 - Structure and function of bacterial secretion systems
Grantee:Shaker Chuck Farah
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/02178-2 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells
Grantee:Ethel Bayer Santos
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/01852-4 - Functional Studies on Xanthomonas citri Type VI Secretion System and Gene Regulation by Alternative Sigma Factors
Grantee:Cristina Elisa Alvarez Martinez
Support Opportunities: Regular Research Grants
FAPESP's process: 17/02318-9 - Functional studies of the Xanthomonas citri pv. citri type 6 secretion system: secreted proteins, recruitment and regulation
Grantee:Lucas de Moraes Ceseti
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)