| Full text | |
| Author(s): |
Bayer-Santos, Ethel
[1]
;
Ceseti, Lucas de Moraes
[2]
;
Farah, Chuck Shaker
[3]
;
Alvarez-Martinez, Cristina Elisa
[2]
Total Authors: 4
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Microbiol, Sao Paulo - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Genet Evolucao Microbiol & Imunol, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Review article |
| Source: | FRONTIERS IN MICROBIOLOGY; v. 10, JUL 17 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Members of the Xanthomonadales order include several plant pathogens of significant economic and agricultural impact, such as Xanthomonas spp. Type 6 secretion systems (T6SSs) are contractile nanomachines used by many bacterial species to inject protein effectors into target prokaryotic and eukaryotic cells and provide a competitive advantage for bacteria in different environments. Effectors with antibacterial properties include peptidoglycan hydrolases, lipases and phospholipases that break down structural components of the cell envelope, promoting target-cell lysis; and RNases, DNAses, and NADases that affect target-cell metabolism, arresting growth. Effectors with anti-eukaryotic properties are functionally more diverse. The T6SS of Xanthomonas citri is the only example experimentally characterized so far within the Xanthomonadales order and displays anti-eukaryotic function by providing resistance to predation by amoeba. This T6SS is regulated at the transcriptional level by a signaling cascade involving a Ser/Thr kinase and an extracytoplasmic function (ECF) sigma factor. In this review, we performed in silico analyses of 35 genomes of Xanthomonadales and showed that T6SSs are widely distributed and phylogenetically classified into three major groups. In silico predictions identified a series of proteins with known toxic domains as putative T6SS effectors, suggesting that the T6SSs of Xanthomonadales display both anti-prokaryotic and anti-eukaryotic properties depending on the phylogenetic group and bacterial species. (AU) | |
| FAPESP's process: | 18/04553-8 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells |
| Grantee: | Ethel Bayer Santos |
| Support type: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 17/17303-7 - Structure and function of bacterial secretion systems |
| Grantee: | Shaker Chuck Farah |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 17/02178-2 - Function of type VI secretion systems of pathogenic bacteria in the interaction with eukaryotic cells |
| Grantee: | Ethel Bayer Santos |
| Support type: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 18/01852-4 - Functional Studies on Xanthomonas citri Type VI Secretion System and Gene Regulation by Alternative Sigma Factors |
| Grantee: | Cristina Elisa Alvarez Martinez |
| Support type: | Regular Research Grants |
| FAPESP's process: | 17/02318-9 - Functional studies of the Xanthomonas citri pv. citri type 6 secretion system: secreted proteins, recruitment and regulation |
| Grantee: | Lucas de Moraes Ceseti |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |