| Full text | |
| Author(s): |
Total Authors: 2
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| Affiliation: | [1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Sao Paulo - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 9, JUL 4 2019. |
| Web of Science Citations: | 2 |
| Abstract | |
Regeneration is classically demonstrated in mammals using mice digit tip. In this study, we compared different amputation plans and show that distally amputated digits regrow with morphology close to normal but fail to regrow the fat pad. Proximally amputated digits do not regrow the phalangeal bone, but the remaining structures (nail, skin and connective tissue), all with intrinsic regenerative capacity, re-establishing integrity indistinguishably in distally and proximally amputated digits. Thus, we suggest that the bone growth promoted by signals and progenitor cells not removed by distal amputations is responsible for the re-establishment of a drastically different final morphology after distal or proximal digit tip amputations. Despite challenging the use of mouse digit tip as a model system for limb regeneration in mammals, these findings evidence a main role of bone growth in digit tip regeneration and suggest that mechanisms that promote joint structures formation should be the main goal of regenerative medicine for limb and digit regrowth. (AU) | |
| FAPESP's process: | 12/09602-0 - Characterization of the gene regulatory network controled by Coup-TFII in cardiomyocytes derived from embryonic stem cells |
| Grantee: | Henrique Marques Barbosa de Souza |
| Support Opportunities: | Research Grants - Young Investigators Grants |