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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chaperones and Beyond as Key Players in Pluripotency Maintenance

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de Lima Fernandes, Camila Felix [1] ; Iglesia, Rebeca Piatniczka [1] ; Melo-Escobar, Maria Isabel [1] ; Prado, Mariana Brandao [1] ; Lopes, Marilene Hohmuth [1]
Total Authors: 5
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Web of Science Citations: 1

Pluripotency is orchestrated by distinct players and chaperones and their partners have emerged as pivotal molecules in proteostasis control to maintain stemness. The proteostasis network consists of diverse interconnected pathways that function dynamically according to the needs of the cell to quality control and maintain protein homeostasis. The proteostasis machinery of pluripotent stem cells (PSCs) is finely adjusted in response to distinct stimuli during cell fate commitment to determine successful organism development. Growing evidence has shown different classes of chaperones regulating crucial cellular processes in PSCs. Histones chaperones promote proper nucleosome assembly and modulate the epigenetic regulation of factors involved in PSCs' rapid turnover from pluripotency to differentiation. The life cycle of pluripotency proteins from synthesis and folding, transport and degradation is finely regulated by chaperones and co-factors either to maintain the stemness status or to cell fate commitment. Here, we summarize current knowledge of the chaperone network that govern stemness and present the versatile role of chaperones in stem cells resilience. Elucidation of the intricate regulation of pluripotency, dissecting in detail molecular determinants and drivers, is fundamental to understanding the properties of stem cells in order to provide a reliable foundation for biomedical research and regenerative medicine. (AU)

FAPESP's process: 19/11097-1 - Modulation of the neural phenotype of glioblastoma stem cells by extracellular miRNA from NSCs
Grantee:Maria Isabel Melo Escobar
Support type: Scholarships in Brazil - Master
FAPESP's process: 18/19320-9 - Gene profiling of embryonic stem cells haploinsufficient for STI1 in the maintenance of pluripotent status
Grantee:Camila Felix de Lima Fernandes
Support type: Scholarships in Brazil - Master
FAPESP's process: 19/12710-9 - Role of cellular prion protein in temozolomide resistance: emphasis on processes modulated by hypoxia
Grantee:Rebeca Piatniczka Iglesia
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/15557-4 - Prion protein and its partners: emerging targets for glioblastoma stem cell based-therapy
Grantee:Marilene Hohmuth Lopes
Support type: Research Grants - Young Investigators Grants - Phase 2
FAPESP's process: 17/20271-0 - Role of prion protein in the dynamic of multiprotein signaling modules related to stemness of glioblastoma stem cells: its functional role and potential therapeutic target
Grantee:Marilene Hohmuth Lopes
Support type: Regular Research Grants
FAPESP's process: 17/26158-0 - Prion protein as stem regulator in glioblastoma stem cells: its role in the formation and function of multiprotein signaling platforms
Grantee:Mariana Brandão Prado
Support type: Scholarships in Brazil - Doctorate (Direct)