| Full text | |
| Author(s): |
de Lima Fernandes, Camila Felix
[1]
;
Iglesia, Rebeca Piatniczka
[1]
;
Melo-Escobar, Maria Isabel
[1]
;
Prado, Mariana Brandao
[1]
;
Lopes, Marilene Hohmuth
[1]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Review article |
| Source: | FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY; v. 7, AUG 2 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Pluripotency is orchestrated by distinct players and chaperones and their partners have emerged as pivotal molecules in proteostasis control to maintain stemness. The proteostasis network consists of diverse interconnected pathways that function dynamically according to the needs of the cell to quality control and maintain protein homeostasis. The proteostasis machinery of pluripotent stem cells (PSCs) is finely adjusted in response to distinct stimuli during cell fate commitment to determine successful organism development. Growing evidence has shown different classes of chaperones regulating crucial cellular processes in PSCs. Histones chaperones promote proper nucleosome assembly and modulate the epigenetic regulation of factors involved in PSCs' rapid turnover from pluripotency to differentiation. The life cycle of pluripotency proteins from synthesis and folding, transport and degradation is finely regulated by chaperones and co-factors either to maintain the stemness status or to cell fate commitment. Here, we summarize current knowledge of the chaperone network that govern stemness and present the versatile role of chaperones in stem cells resilience. Elucidation of the intricate regulation of pluripotency, dissecting in detail molecular determinants and drivers, is fundamental to understanding the properties of stem cells in order to provide a reliable foundation for biomedical research and regenerative medicine. (AU) | |
| FAPESP's process: | 18/15557-4 - Prion protein and its partners: emerging targets for glioblastoma stem cell based-therapy |
| Grantee: | Marilene Hohmuth Lopes |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 17/26158-0 - Prion protein as stem regulator in glioblastoma stem cells: its role in the formation and function of multiprotein signaling platforms |
| Grantee: | Mariana Brandão Prado |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 18/19320-9 - Gene profiling of embryonic stem cells haploinsufficient for STI1 in the maintenance of pluripotent status |
| Grantee: | Camila Felix de Lima Fernandes |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 19/12710-9 - Role of cellular prion protein in temozolomide resistance: emphasis on processes modulated by hypoxia |
| Grantee: | Rebeca Piatniczka Iglesia |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 19/11097-1 - Modulation of the neural phenotype of glioblastoma stem cells by extracellular miRNA from NSCs |
| Grantee: | Maria Isabel Melo Escobar |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/20271-0 - Role of prion protein in the dynamic of multiprotein signaling modules related to stemness of glioblastoma stem cells: its functional role and potential therapeutic target |
| Grantee: | Marilene Hohmuth Lopes |
| Support Opportunities: | Regular Research Grants |