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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of Justicia acuminatissima, or Amazonian Sara Tudo, on ischemic acute kidney injury: an experimental study

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Author(s):
Cordeiro, Priscilla Mendes [1] ; Fernandes, Sheila Marques [2] ; da Fonseca, Cassiane Dezoti [2] ; Watanabe, Mirian [2] ; Lopes, Sergio Martins [2] ; Fernandes Vattimo, Maria de Fatima [2]
Total Authors: 6
Affiliation:
[1] Univ Fed Amazonas, Colegiado Enfermagem, Manaus, Amazonas - Brazil
[2] Univ Sao Paulo, Escola Enfermagem, Lab Expt Modelos Animais, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Revista da Escola de Enfermagem da USP; v. 53, 2019.
Web of Science Citations: 0
Abstract

Objective: To evaluate the effects of Justicia acuminatissima, or Amazonian Sara Tudo, on renal hemodynamics, oxidative profile, and renal histology in rats with ischemic acute kidney injury. Method: Preclinical assay with adult male Wistar rats, weighing from 250 g to 350 g, distributed into Sham, ischemia, and ischemia + Sara Tudo groups. Hemodynamic parameters, renal function, oxidative stress, and renal histology were evaluated. Results: Pretreatment with Sara Tudo reduced the functional injury, which was shown by the increase in creatinine clearance and thiols; reduction of oxidative markers, renal vascular resistance, and tubulointerstitial injury in the renal tissue; and the significant improvement in renal blood flow. Conclusion: The renoprotection provided by Justicia acuminatissima, or Sara Tudo, in cases of ischemic acute kidney injury was characterized by a marked improvement in renal function, reducing the oxidative injury, and impacting on renal histology positively. (AU)

FAPESP's process: 11/24028-6 - EFFECT OF PHOSPHODIESTERASE-5 INIBITOR IN ISCHEMIC ACUTE KIDNEY INJURY IN RATS
Grantee:Mirian Watanabe
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/26560-2 - Iodinated contrast induced acute kidney injury in diabetic and nephropathy diabetic in rats
Grantee:Maria de Fatima Fernandes Vattimo
Support type: Regular Research Grants