| Full text | |
| Author(s): |
Total Authors: 4
|
| Affiliation: | [1] Federal University of São Paulo. Institute of Science and Technology. Bioceramics Laboratory - Brasil
[2] Federal University of São Paulo. Institute of Science and Technology. Bioceramics Laboratory - Brasil
[3] Federal University of São Paulo. Institute of Science and Technology. Bioceramics Laboratory - Brasil
[4] Federal University of São Paulo. Institute of Science and Technology. Bioceramics Laboratory - Brasil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Cerâmica; v. 65, n. 374, p. 261-266, 2019-06-06. |
| Abstract | |
Abstract Calcium phosphate cements (CPCs) are potential materials for repairing bone defects, mainly due to their excellent biocompatibility and osteoconductivity. Nevertheless, their low mechanical properties limit their usage in clinical applications. The gelatin addition may improve the mechanical and biological properties of CPCs, but their solubility in water may increase the porosity of the cement during degradation. Thus, the aim of this work was to investigate the influence of gelatin on the setting time, compressive strength and degradation rate of a brushite cement. CPCs were prepared with the addition of 0, 5, 10 and 20 wt% of gelatin powder in the solid phase of the cement. The results indicated that the setting time increased with gelatin. Furthermore, cement with 20 wt% of gelatin had an initial compressive strength of 14.1±1.8 MPa while cement without gelatin had 4.5±1.2 MPa. The weight loss, morphology and compressive strength were evaluated after degradation in Ringer’s solution. According to the weight loss data, gelatin was eliminated of samples during degradation. It was concluded that the presence of gelatin improved CPCs mechanical properties; however, as degradation in Ringer’s solution evolved, cement compressive strength decreased due to gelatin dissolution and, consequently, an increase in sample porosity. (AU) | |
| FAPESP's process: | 13/19642-2 - Injectable bone cements: optimizing and controlling mechanical resistance, porosity and degradation rate |
| Grantee: | Mariana Motisuke |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/09240-9 - Calcium phosphate cement otimization for application in orthopedics and tissue engineering |
| Grantee: | Mariana Motisuke |
| Support Opportunities: | Regular Research Grants |