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Injectable bone cements: optimizing and controlling mechanical resistance, porosity and degradation rate

Abstract

Developing materials that could be implanted by minimally invasive surgeries and, at the same time, that allow and induce tissue`s treatment and growth is becoming a key path for enhancing people`s life quality. Thus, injectable materials, i.e. injectable calcium phosphate cements (iCPC), are strategic to suit the new trends in the biomaterials market and research field. Besides of being biocompatible, biactive and resorbable; CPC could become injectable by simply controlling its viscosity. Nevertheless, by reducing paste viscosity other CPC`s properties like mechanical resistance, setting and cohesion time, porosity and resorbability are impaired. Moreover, many surgeons complain that many CPC pastes are poorly injectable and most of the times lead to phase segregation during injection. Another drawback of commercial iCPCs is the difficulty in maintaining material`s cohesion after implantation. As a result, the number of publication focusing in studying and developing injectable CPC are growing fast. Basically, all studies concluded that by increasing liquid-powder ratio and/or adding polymeric additives and/or employing round particles are sufficient to enhance iCPC injectability. Nonetheless, mechanical resistance and porosity is poorly studied and it is well known that these properties are key factors for the clinical success of these materials. In this context, the aim of this research project is to develop new formulations of iCPCs by optimising the correlation between injectability and mechanical resistance/ resorbability and porosity leading to new materials that could be empoyed for treating bone or dental tissues. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, RODRIGO L. M. S.; MOTISUKE, MARIANA. Using round ?-TCP granules for improving CPC injectability. MATERIALS RESEARCH EXPRESS, v. 6, n. 12 DEC 2019. Web of Science Citations: 0.
L. P. SILVA; M. D. P. RIBEIRO; E. S. TRICHÊS; M. MOTISUKE. Brushite cement containing gelatin: evaluation of mechanical strength and in vitro degradation. Cerâmica, v. 65, n. 374, p. 261-266, Jun. 2019.
C. O. RENÓ; R. G. CARRODEGUAS; M. MOTISUKE; M. A. RODRÍGUEZ. Preparation and properties of α-tricalcium phosphate microspheres by spray drying. Cerâmica, v. 65, n. 376, p. 599-604, Dez. 2019.
RENO, CAROLINE DE OLIVEIRA; MOTISUKE, MARIANA. Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 19, n. 6, p. 1388-1392, NOV-DEC 2016. Web of Science Citations: 1.
CAROLINE DE OLIVEIRA RENÓ; MARIANA MOTISUKE. Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 19, n. 6, p. 1388-1392, Dez. 2016.

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