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Strotium and silicon co-doped calcium phosphate cement: injectability evaluation and mechanical properties optimization

Grant number: 13/26248-9
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2014
Effective date (End): July 31, 2017
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal researcher:Mariana Motisuke
Grantee:Caroline de Oliveira Renó
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil
Associated scholarship(s):15/01672-8 - Silicon and strontium co-doped calcium phosphate scaffolds obtained by 3D printing, BE.EP.DD


Developing materials that could be implanted by minimally invasive surgeries and, at the same time, that allow and induce tissue´s treatment and growth is becoming a key path for enhancing people´s life quality. Thus, injectable materials, i.e., injectable Calcium Phosphate Cements (iCPC), are strategic to suit the new trends in the biomaterials market and research field. Besides of being biocompatible, biactive and resorbable; CPC could become injectable by simply controlling its viscosity. Nevertheless, by reducing paste viscosity other CPC´s properties like mechanical resistance, setting and cohesion time, porosity and resorbability are impaired. Moreover, many surgeons complain that many CPC pastes are poorly injectable and most of the times lead to phase segregation during injection. Another drawback of commercial iCPCs is the difficulty in maintaining material´s cohesion after implantation. As a result, the number of publication focusing in studying and developing injectable CPC are growing fast. Basically, all studies concluded that by increasing liquid-powder ratio and/or adding polymeric additives and/or employing round particles are sufficient to enhance iCPC injectability. Nonetheless, mechanical resistance and porosity is poorly studied and it is well known that these properties are key factors for the clinical success of these materials. In this context, the aim of this research project is to develop new iCPCs base on Sr and Si co-doped [alpha]-TCP reinforced by wollastonite fibers. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
C. O. RENÓ; R. G. CARRODEGUAS; M. MOTISUKE; M. A. RODRÍGUEZ. Preparação e caracterização de microesferas de a -fosfato tricálcico obtidas por spray drying. Cerâmica, v. 65, n. 376, p. 599-604, . (13/03208-1, 13/26248-9, 13/19642-2)
RENO, CAROLINE DE OLIVEIRA; MOTISUKE, MARIANA. Optimizing the Water-Oil Emulsification Process for Developing CPC Microspheres. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 19, n. 6, p. 1388-1392, . (12/21198-0, 13/26248-9, 13/19642-2, 11/09240-9)

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