Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Treatment of experimental periodontal disease with antimicrobial photodynamic therapy in nicotine-modified rats

Full text
Garcia, Valdir Gouveia [1, 2] ; Fernandes, Leandro Araujo [3, 1] ; Macarini, Valmir Campos [1] ; de Almeida, Juliano Milanezi [1] ; Martins, Thiago Marchi [1] ; Bosco, Alvaro Francisco [1] ; Hitomi Nagata, Maria Jose [1] ; Cirelli, Joni Augusto [4] ; Theodoro, Leticia Helena [1, 2]
Total Authors: 9
[1] Sao Paulo State Univ, Grp Res & Study Laser Dent GEPLO, Dept Surg, Div Periodont, Sao Paulo - Brazil
[2] Educ Fdn Barretos UNIFEB, Dent Sch Barretos, Univ Ctr, Master Course, Barretos, SP - Brazil
[3] Univ Fed Alfenas, Dept Clin & Surg, Alfenas, MG - Brazil
[4] Sao Paulo State Univ, Dept Diag & Surg, Div Periodont, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 38, n. 12, p. 1106-1114, DEC 2011.
Web of Science Citations: 24

Background: The aim of this study was to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to scaling and root planing (SRP) for induced periodontitis in nicotine-modified rats. Material \& Methods: A total of 240 rats were evenly divided into two groups: C - saline solution treatment; N - nicotine treatment. Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed. All animals were submitted to SRP and were divided according to the following treatments: SRP - irrigation with saline solution; Toluidine Blue-O (TBO) - irrigation with phenothiazinium dye (100 mu g/ml); LLLT - laser irradiation (660 nm; 0.03 W; 4 J); and aPDT - TBO and laser irradiation. Ten animals in each group/treatment were euthanized at 7, 15 and 30 days. The histometric and immunohistochemical values were statistically analysed. Results: Intragroup analysis demonstrated that in both groups the aPDT treatment resulted in lower bone loss (BL) when compared to SRP in all experimental periods. Intergroup analysis demonstrated that aPDT treatment resulted in lower BL in Group N than in Group C treated with SRP in all experimental periods. Conclusion: Antimicrobial photodynamic therapy was an effective adjunctive treatment to SRP for induced periodontitis in nicotine-modified rats. (AU)

FAPESP's process: 08/04927-3 - Action of photodynamic therapy on treatment of periodontal disease experimentally induced on rats treated or not with nicotine: histological, histometric and immunohistochemical study
Grantee:Valdir Gouveia Garcia
Support Opportunities: Regular Research Grants