Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

Author(s)

da Cunha, Bianca Rodrigues ^{[1, 2]} ; Domingos, Celia ^{[3, 4]} ; Buzzo Stefanini, Ana Carolina ^{[1, 2]} ; Henrique, Tiago ^[2] ; Polachini, Giovana Mussi ^[2] ; Castelo-Branco, Pedro ^{[3, 4, 5]} ; Tajara, Eloiza Helena ^{[1, 2]}

Affiliation

^[1] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil

^[2] Sch Med Sao Jose do Rio Preto FAMERP, Dept Mol Biol, Av Brig Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Algarve, Dept Biomed Sci & Med, Faro - Portugal

^[4] Univ Algarve, Ctr Biomed Res CBMR, Faro - Portugal

^[5] Algarve Biomed Ctr, Faro - Portugal

• Document type: Review article
• Source: JOURNAL OF CANCER; v. 10, n. 19, p. 4574-4587, 2019.
• Web of Science Citations: 0

Abstract

Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses. (AU)

• FAPESP's process: 13/03839-1 - Study of the interactions between cells from the carcinoma of head and neck and its microenvironment
• Grantee: Eloiza Helena Tajara da Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/06048-2 - Analysis of the secretome of head and neck carcinoma and its effect on the tumor microenvironment
• Grantee: Bianca Rodrigues da Cunha
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
• Grantee: Eloiza Helena Tajara da Silva
• Support Opportunities: Research Projects - Thematic Grants