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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cellular Interactions in the Tumor Microenvironment: The Role of Secretome

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da Cunha, Bianca Rodrigues [1, 2] ; Domingos, Celia [3, 4] ; Buzzo Stefanini, Ana Carolina [1, 2] ; Henrique, Tiago [2] ; Polachini, Giovana Mussi [2] ; Castelo-Branco, Pedro [3, 4, 5] ; Tajara, Eloiza Helena [1, 2]
Total Authors: 7
[1] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, SP - Brazil
[2] Sch Med Sao Jose do Rio Preto FAMERP, Dept Mol Biol, Av Brig Faria Lima 5416, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[3] Univ Algarve, Dept Biomed Sci & Med, Faro - Portugal
[4] Univ Algarve, Ctr Biomed Res CBMR, Faro - Portugal
[5] Algarve Biomed Ctr, Faro - Portugal
Total Affiliations: 5
Document type: Review article
Source: JOURNAL OF CANCER; v. 10, n. 19, p. 4574-4587, 2019.
Web of Science Citations: 0

Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix. These components of the tumor microenvironment and the neoplastic cells interact with each other providing pro and antitumor signals. The tumor-stroma communication occurs directly between cells or via a variety of molecules secreted, such as growth factors, cytokines, chemokines and microRNAs. This secretome, which derives not only from tumor cells but also from cancer-associated stromal cells, is an important source of key regulators of the tumorigenic process. Their screening and characterization could provide useful biomarkers to improve cancer diagnosis, prognosis, and monitoring of treatment responses. (AU)

FAPESP's process: 13/03839-1 - Study of the interactions between cells from the carcinoma of head and neck and its microenvironment
Grantee:Eloiza Helena Tajara da Silva
Support type: Regular Research Grants
FAPESP's process: 12/06048-2 - Analysis of the secretome of head and neck carcinoma and its effect on the tumor microenvironment
Grantee:Bianca Rodrigues da Cunha
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants