New cathepsin V inhibitor from stems of Bowdichia virgilioides

Author(s)

Silva, Taynara L. ^[1] ; Fernandes, Joao B. ^[1] ; Silva, M. Fatima das G. F. ^[1] ; Consolaro, Helder N. ^[2] ; de Sousa, Lorena R. F. ^{[1, 2]} ; Vieira, Paulo C. ^{[3, 1]}

Affiliation

^[1] Univ Fed Sao Carlos, Dept Quim, Sao Carlos, SP - Brazil

^[2] Univ Fed Goias Reg Catalano, Unidade Acad Especial Quim, Catalano, Go - Brazil

^[3] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 29, n. 4, p. 491-494, JUL-AUG 2019.
• Web of Science Citations: 0

Abstract

Abstract Bioassay-guided fractionation of Bowdichia virgilioides Kunth, Fabaceae, extracts has led to the isolation of cathepsin V inhibitors. The investigation of the hexane and ethyl acetate extracts allowed the characterization of eleven compounds: lupeol, lupenone, β-sitosterol and stigmasterol in mixture, trans p-coumaric acid ester derivative, syringaresinol, bowdenol, 8-methoxycoumestrol, 3,4-hydroxy-7-methoxyisoflavone, 7,3′-dihydroxy-4′-methoxyisoflavone, and 5,4′-dihydroxy-7′-methoxyisoflavone. Structures of compounds were stablished by 1D and 2D NMR, and MS experiments. Among the isolated compounds, trans p-coumaric acid ester derivative and 8-methoxycoumestrol showed significant inhibition on cathepsin V, which is up to now unexplored. (AU)

• FAPESP's process: 12/25299-6 - Integrated studies for leaf cutting control
• Grantee: João Batista Fernandes
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 12/11819-8 - Chemical study of Bowdichia virgilioides (Fabaceae) on searching for selective inhibitors of cysteine peptidases.
• Grantee: Taynara Lopes Silva
• Support Opportunities: Scholarships in Brazil - Master