| Full text | |
| Author(s): |
Dias, Anderson A.
[1]
;
Chagas, Cyro L. S.
[2]
;
Silva-Neto, Habdias de A.
[1]
;
Lobo-Junior, Eulicio O.
[1]
;
Sgobbi, Livia F.
[1]
;
de Araujo, William R.
[3]
;
Paixao, Thiago R. L. C.
[2, 4]
;
Coltro, Wendell K. T.
[1, 4]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed Goias, Inst Quim, BR-74690900 Goiania, Go - Brazil
[2] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
[3] Univ Estadual Campinas, Inst Quim, Dept Quim Analit, BR-13083970 Campinas, SP - Brazil
[4] Inst Nacl Ciencia & Tecnol Bioanalit, BR-13084971 Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | ACS APPLIED MATERIALS & INTERFACES; v. 11, n. 43, p. 39484-39492, OCT 30 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Electrochemical sensors based on graphite and polymers have emerged as powerful analytical tools for bioanalytical applications. However, most of the fabrication processes are not environmentally friendly because they often involve the use of toxic reagents and generate waste. This study describes an alternative method to produce flexible electrodes in plastic substrates using graphite powder and thermal laminating sheets by solid-solid deposition through hot compression, without the use of hazardous chemical reagents. The electrodes developed through the proposed approach have successfully demonstrated flexibility, robustness, reproducibility (relative standard deviation around 6%), and versatility. The electrodes were thoroughly characterized by cyclic voltammetry, electrochemical impedance spectroscopy, Raman spectroscopy, and scanning electron microscopy. As a proof of concept, the electrode surfaces were modified with bismuth and used for zinc analysis in sweat. The modified electrodes presented linearity (R-2 = 0.996) for a wide zinc concentration range (50-2000 ppb) and low detection limit (4.31 ppb). The proposed electrodes were tested using real sweat samples and the achieved zinc concentrations did not differ statistically from the data obtained by atomic absorption spectroscopy. To allow wearable applications, a 3D-printed device was fabricated, integrated with the proposed electrochemical system, and fixed at the abdomen by using an elastic tape to collect, store, and analyze the sweat sample. The matrix effect test was performed, spiking the real sample with different zinc levels, and the recovery values varied between 85 and 106%, thus demonstrating adequate accuracy and robustness of the flexible electrodes developed based on the proposed fabrication method. (AU) | |
| FAPESP's process: | 17/10522-5 - Development of alternative methods for fabrication of electrochemical paper-based sensors |
| Grantee: | Thiago Regis Longo Cesar da Paixão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications |
| Grantee: | Mauro Bertotti |
| Support Opportunities: | Research Projects - Thematic Grants |