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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Depression and Coping Are Associated with Failure of Adherence to Antiretroviral Therapy Among People Living with HIV/AIDS

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Author(s):
Camargo, Caio C. [1] ; Cavassan, Nayara R. V. [1] ; Tasca, Karen I. [1] ; Meneguin, Silmara [2] ; Miot, Helio A. [3] ; Souza, Lenice R. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista UNESP, Dept Trop Dis, Botucatu Med Sch FMB, Rua Antonio Brasilino Favero 289, BR-18610101 Botucatu, SP - Brazil
[2] Univ Estadual Paulista UNESP, Dept Nursing, Botucatu Med Sch FMB, Botucatu, SP - Brazil
[3] Univ Estadual Paulista UNESP, Dept Dermatol, Botucatu Med Sch FMB, Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AIDS Research and Human Retroviruses; v. 35, n. 11-12, p. 1181-1188, NOV 1 2019.
Web of Science Citations: 1
Abstract

Sustained adherence to antiretroviral therapy (ART) is critical in the prevention of drug resistance, disease progression, and death. We aimed to assess the level of ART adherence among 112 people living with HIV/AIDS (PLWHA) and to determine associated factors with that. The socioeconomic aspects were evaluated by medical records; the adherence, depression, and coping by specific questionnaires. Although most patients have undetectable viral load (79%) and CD4(+) T count >500 cells/mm(3) (65%), two-third (66%) of them exhibited a lower adherence, which was directly associated with some signs of depression (p = .006) presented by 65% of them. Some risk factors to presence of depression were female gender (p = .008) and low income (p = .013). In addition, most participants who reported tobacco (33%) and alcohol (29%) consumption had a low or intermediate adherence score. Among the coping strategies, self-control (p = .029), social support (p = .006), problem solving (p = .013), and positive reappraisal (p = .049) led to an improvement in adherence. (AU)

FAPESP's process: 16/15440-4 - Early aging in people living with HIV/AIDS: pathophysiology, comorbidities and the interference of antiretrovirals
Grantee:Lenice Do Rosário de Souza
Support Opportunities: Regular Research Grants