| Full text | |
| Author(s): |
Figuereido Leite, Giuseppe Gianini
[1]
;
Scicluna, Brendon P.
[2, 3]
;
van Der Poll, Tom
[2, 3]
;
Salomao, Reinaldo
[1]
Total Authors: 4
|
| Affiliation: | [1] Univ Fed Sao Paulo, Div Infect Dis, Dept Med, Hosp Sao Paulo, Escola Paulista Med, Sao Paulo - Brazil
[2] Univ Amsterdam, Ctr Expt & Mol Med, Amsterdam Univ Med Ctr, Locat Acad Med Ctr, Amsterdam - Netherlands
[3] Univ Amsterdam, Ctr Infect & Immun Amsterdam, Amsterdam Univ Med Ctr, Locat Acad Med Ctr, Amsterdam - Netherlands
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | NPJ SYSTEMS BIOLOGY AND APPLICATIONS; v. 5, AUG 1 2019. |
| Web of Science Citations: | 0 |
| Abstract | |
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated inflammatory response to pathogens. Bioinformatics and transcriptomics studies contribute to get a better understanding of the pathogenesis of sepsis. These studies revealed differentially expressed genes (DEGs) in sepsis involved in several pathways. Here we investigated the gene expression profiles of blood leukocytes using three microarray datasets of sepsis secondary to pneumonia, focusing on the heme/hemoglobin metabolism pathway. We demonstrate that the heme/hemoglobin metabolism pathway was found to be enriched in these three cohorts with four common genes (ALAS2, AHSP, HBD, and CA1). Several studies show that these four genes are involved in the cytoprotection of non-erythrocyte cells in response to different stress conditions. The upregulation of heme/hemoglobin metabolism in sepsis might be a protective response of white cells to the hostile environment present in septic patients (follow-up samples). (AU) | |
| FAPESP's process: | 17/21052-0 - Sepsis: mechanisms, therapeutic targets and epidemiology |
| Grantee: | Reinaldo Salomão |
| Support Opportunities: | Research Projects - Thematic Grants |