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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genome-wide mapping of the dominance effects based on breed ancestry for semen traits in admixed Swiss Fleckvieh bulls

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Author(s):
Khayatzadeh, N. [1] ; Meszaros, G. [1] ; Utsunomiya, Y. T. [2] ; Schmitz-Hsu, F. [3] ; Seefried, F. [4] ; Schnyder, U. [4] ; Ferencakovic, M. [5] ; Garcia, J. F. [2, 6] ; Curik, I [5] ; Soelkner, J. [1]
Total Authors: 10
Affiliation:
[1] Univ Nat Resources & Life Sci Vienna BOKU, Dept Sustainable Agr Syst, Div Livestock Sci, Gregor Mendel Str 33, A-1180 Vienna - Austria
[2] Univ Estadual Paulista, UNESP, Fac Cinecias Agr Vet, Dept Med Vet Prevent & Reprod Anim, BR-16050680 Aracatuba, SP - Brazil
[3] Swissgenet, Meielenfeldweg 12, CH-3052 Postfach, Zollikofen - Switzerland
[4] Qualitas AG, Chamerstr 56, CH-6300 Zug - Switzerland
[5] Univ Zagreb, Fac Agr, Dept Anim Sci, Svetosimunska Cesta 25, Zagreb 10000 - Croatia
[6] Univ Estadual Paulista, UNESP, Fac Med Vet Aracatuba, Dept Apoio Saude & Prod Anim, Brazil 16050-680, BR-16050680 Aracatuba, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF DAIRY SCIENCE; v. 102, n. 12, p. 11217-11224, DEC 2019.
Web of Science Citations: 0
Abstract

Heterosis is the beneficial deviation of crossbred progeny from the average of parental lines for a particular trait. Heterosis is due to nonadditive genetic effects with dominance arid epistatic components. Recent advances in genotyping technology have encouraged researchers to estimate and scan heterosis components for a range of traits in crossbred populations, applying various definitions of such components. In this study, we defined the intralocus (dominance) component of heterosis using local genetic ancestry and performed genome-wide association analysis for admixed Swiss Fleckvieh bulls arid their parental populations, Red Holstein Friesian and Swiss Simmental, for semen traits. A linear mixed model for 41,824 SNP, including SNP additive genetic, breed additive, and breed dominance effects on 1,178 bulls (148 Red Holstein Friesian, 213 Swiss Simmental, and 817 Swiss Fleckvieh) with a total of 43,782 measurements was performed. In total, 19 significant regions for breed dominance were identified for volume (2 regions on Bos taurus autosome 10 and 22) and percentage of live spermatozoa (17 regions on Dos taurus autosome 3, 4, 5, 7, 13, 14, and 17), and genes associated with spermatogenesis, sperm motility, and male fertility traits were located there. No significant region for breed dominance was detected for total number of spermatozoa. The signals for breed dominance were relatively wide, most likely due to limited numbers of recombination events in a small number of generations (10-15 generations) of crossbreeding in the recent Swiss Fleckvieh composite. (AU)

FAPESP's process: 16/07531-0 - Comparison of methods for admixture and heterosis mapping in crossbred cattle populations
Grantee:Yuri Tani Utsunomiya
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 14/01095-8 - Use of next generation sequencing for the fine mapping of loci explaining variance in scrotal circumference in Nellore cattle
Grantee:Yuri Tani Utsunomiya
Support type: Scholarships in Brazil - Doctorate