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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anthropometric measures associated with sarcopenia in outpatients with liver cirrhosis

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Author(s):
Santos, Livia A. A. [1] ; Lima, Talles B. [1] ; do Val Ietsugu, Marjorie [1] ; de Carvalho Nunes, Helio R. [2] ; Qi, Xingshun [3] ; Romeiro, Fernando G. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Internal Med, Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Publ Hlth, Sao Paulo, SP - Brazil
[3] Shenyang Mil Command, Gen Hosp, Shenyang, Liaoning - Peoples R China
Total Affiliations: 3
Document type: Journal article
Source: NUTRITION & DIETETICS; v. 76, n. 5, p. 613-619, NOV 2019.
Web of Science Citations: 2
Abstract

Aim The present study aimed to identify variables associated with sarcopenia in cirrhotic outpatients using clinical data, anthropometric measures and lab tests. In a single centre prospective study, 261 cirrhotic outpatients were followed on average for 2 years. The diagnostic criteria of sarcopenia were applied according to the current guidelines, combining muscle strength and appendicular muscle mass index. Methods Age, sex, liver disease aetiology and the Model of End-Stage Liver Disease score were included as independent variables, as well as mid-arm circumference (MAC), body mass index and triceps skinfold. Multiple logistic regression was applied including all independent variables (maximum model). Then, the analysis was performed only with the variables that were significant in the first analysis (parsimonious model). Once the variable most related to sarcopenia was determined by the two models, the area under the receiver operator characteristic curve was calculated. Mortality rates were described for patients with and without sarcopenia. Results Sarcopenia was diagnosed in 14 subjects (5.36%), and the variable best associated with sarcopenia was MAC (P < 0.01). The 1-year mortality rate of 35.71% found among subjects with sarcopenia was not significantly higher (P = 0.07) than the 15.38% observed among those without this condition. Conclusions Before examinations requiring ionising radiation, patients with cirrhosis can be submitted to simple screening tools to identify those who have a high risk of sarcopenia, thus promoting a cost-effective assessment. (AU)

FAPESP's process: 17/25592-9 - Objective tumoral response, safety profile and survival rates of patients with liver cirrhosis and hepatocellular carcinoma of intermediate stage submitted to Radioembolization with 131I-Lipiodol versus Transarterial Chemoembolization
Grantee:Fernando Gomes Romeiro
Support Opportunities: Regular Research Grants
FAPESP's process: 16/07117-9 - Risedronate for osteoporosis treatment in patients with liver cirrhosis and esophageal varices: assessment on safety profile and bone mass
Grantee:Fernando Gomes Romeiro
Support Opportunities: Regular Research Grants
FAPESP's process: 14/22572-9 - Bone changes in patients with liver cirrhosis treated for osteoporosis and osteopenia
Grantee:Lívia Alves Amaral Santos
Support Opportunities: Scholarships in Brazil - Doctorate