Synthesis of long-chain polyols from the Claisen condensation of gamma-valerolactone

Author(s)

Santos, Camila S. ^[1] ; Soares, Caio C. S. P. ^[2] ; Vieira, Adriano S. ^[3] ; Burtoloso, Antonio C. B. ^[1]

Affiliation

^[1] Univ Sao Paulo, Chem Inst Sao Carlos, BR-13560970 Sao Paulo, SP - Brazil

^[2] Brazilian Ctr Res Energy & Mat CNPEM, Brazilian Biorenewables Natl Lab LNBR, BR-13083970 Campinas, SP - Brazil

^[3] Eurofarma Labs SA, Rodovia Castelo Branco 3-565, Itapevi, SP - Brazil

• Document type: Journal article
• Source: GREEN CHEMISTRY; v. 21, n. 23, p. 6441-6450, DEC 7 2019.
• Web of Science Citations: 0

Abstract

A novel and direct method for the production of polyols with long chains is developed under simple and mild conditions starting from renewable gamma-valerolactone (GVL), a chemical platform easily obtained from biomass. The key step involves a Claisen condensation between two GVL molecules to provide a cyclic hemiketal in 85% yield. After alkylation and/or reduction, this ketal serves as a new platform to produce several high-value-added branched chain molecules with carbons ranging from C10 to C21. (AU)

• FAPESP's process: 17/23329-9 - Synthesis of substituted cyclopentanes and long chain polyols from abundant chemical platforms derived from biomass
• Grantee: Antonio Carlos Bender Burtoloso
• Support type: Regular Research Grants