Association of dietary components with dyslipidemia and low-grade inflammation biomarkers in adults with heterozygous familial hypercholesterolemia from different countries

Author(s):Show less -

Antoniazzi, Luiza ^[1] ; Arroyo-Olivares, Raquel ^[2] ; Bittencourt, Marcio S. ^{[3, 4]} ; Tada, Mauricio Teruo ^[1] ; Lima, Isabella ^[1] ; Jannes, Cinthia E. ^[1] ; Krieger, Jose E. ^[1] ; Pereira, Alexandre C. ^[1] ; Quintana-Navarro, Gracia ^[5] ; Muniz-Grijalvo, Ovidio ^[6] ; Luis Diaz-Diaz, Jose ^[7] ; Zambon, Daniel ^[8] ; Mata, Pedro ^[2] ; Santos, Raul D. ^{[9, 1]}

Affiliation

^[1] Univ Sao Paulo, Heart Inst InCor, Med Sch Hosp, Sao Paulo, SP - Brazil

^[2] Fdn Hipercolesterolemia Familiar, Madrid - Spain

^[3] Fac Israelita Ciencias Saude Albert Einstein, Sch Med, Sao Paulo, SP - Brazil

^[4] Univ Sao Paulo, Univ Hosp, Ctr Clin & Epidemiol Res, Sch Med, Sao Paulo, SP - Brazil

^[5] Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, IMIBIC, Cordoba - Spain

^[6] Hosp Virgen del Rocio, Serv Med Interna, Seville - Spain

^[7] Hosp Abente & Lago, Serv Med Interna, La Coruna - Spain

^[8] Hosp Clin Barcelona, Serv Endocrinol, Barcelona - Spain

^[9] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: European Journal of Clinical Nutrition; v. 73, n. 12, p. 1622-1625, DEC 2019.
• Web of Science Citations: 0

Abstract

The association of components of a low saturated fat (SFA) and of a Mediterranean diet was tested with atherosclerosis biomarkers in 190 familial hypercholesterolemia adults (FH) from Brazil (BR) and Spain (SP). Median blood LDL-C, Apolipoprotein B (apoB), and C reactive protein (hs-CRP) concentrations were higher in BR than in SP: 179.0 vs.161 mg/dL; 141 vs. 103 mg/dL; and 1.6 vs. 0.8 mg/L respectively (all p < 0.001). In BR there was lower median total fat (22.3 vs. 38.3%) and SFA (8.1 vs. 12.5%) but higher cholesterol (283.3 mg vs.188.9 mg) and carbohydrate (57.1 vs. 42.5%) consumption (all p < 0.001). Inverse associations were encountered between fibers, mono, and polyunsaturated fats and their ratios to SFA with LDL-C and ApoB (all p < 0.001). There was a direct association respectively of cholesterol with lipid biomarkers and of carbohydrates and trans-fatty acids with hs-CRP while other fats showed inverse relations with the latter (p < 0.001). (AU)

• FAPESP's process: 13/17368-0 - Cardiovascular genomics: mechanisms & novel therapeutics - CVGen mech2ther
• Grantee: José Eduardo Krieger
• Support Opportunities: Research Projects - Thematic Grants