Field-testing a single-dose immunocontraceptive in free-ranging male capybara (Hydrochoerus hydrochaeris): Evaluation of effects on reproductive physiology, secondary sexual characteristics, and agonistic behavior

Author(s)

Rosenfield, Derek A. ^[1] ; Nichi, Marcilio ^[1] ; Losano, Joao D. A. ^[1] ; Kawai, Giulia ^[1] ; Leite, Roberta F. ^[1] ; Acosta, Alfredo J. ^[2] ; Baquero, Oswaldo Santos ^[2] ; Pizzutto, Cristiane Schilbach ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Anim Reprod Wildlife, BR-05508270 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Prevent Vet Med & Anim Hlth, Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: Animal Reproduction Science; v. 209, OCT 2019.
• Web of Science Citations: 1

Abstract

Controlling wildlife populations to mitigate human-wildlife conflicts and the spread of zoonotic diseases is an ever-growing necessity. The objective of this study was to evaluate a single-dose anti-gonadotropin-releasing hormone vaccine (GonaCon, USDA/NWRC, Fort Collins, CO, USA) as a non-lethal alternative for population control in free-ranging, synanthropic male capybara. In addition to infertility efficacy of this treatment, potential effects on the alpha male's secondary sexual characteristics and agonist behavior need to be assessed because any alterations in these factors could lead to population management failure. The treatment group (n = 3) received 1 mL of the anti-GnRH vaccine, intramuscularly, and the control group (n = 2) a 1 mL sham vaccine. Reproductive behavior and social group dynamics were monitored for 30 days prior to inoculation (June 2017) with continuous observations occurring during the study period. Antifertility effects were assessed by conducting exams of testicular morphology, semen characteristics, and histological analysis (after 270 days via hemi-gonadectomy). Compared to the control group, the testicles of the treated males had severe atrophy (P < 0.05), oligozoospermia and greater numbers of sperm cells in a static developmental phase. Courtship and agonistic alpha male behavior were not altered, and the group's social integrity was maintained. Results indicate there was 100% infertility in capybara males, observed throughout the study period of 18 months, and equally important, the male's alpha characteristics were not affected by the treatment, which is imperative for successful capybara population control efforts. (AU)

• FAPESP's process: 16/12549-5 - Study on the perspective of non-lethal population control in capybara (Hydrochoerus hydrochaeris) through reversible immunocontraceptive methods
• Grantee: Derek Andrew Rosenfield
• Support Opportunities: Scholarships in Brazil - Doctorate