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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases

Full text
Author(s):
de Godoy, Andre Schutzer [1] ; Fernandes, Rafaela Sachetto [1] ; Campos Aguiar, Anna Caroline [1] ; Bueno, Renata Vieira [1] ; de Moraes Roso Mesquita, Nathalya Cristina [1] ; Carvalho Guido, Rafael Victorio [1] ; Oliva, Glaucius [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Phys Sao Carlos, Ave Joao Dagnone 1100, BR-13563120 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CURRENT OPINION IN STRUCTURAL BIOLOGY; v. 59, p. 65-72, DEC 2019.
Web of Science Citations: 0
Abstract

With almost half of the world population living at risk, tropical infectious diseases cause millions of deaths every year in developing countries. Considering the lack of economic prospects for investment in this field, approaches aiming the rational design of compounds, such as structure-based drug discovery (SBDD), fragment screening, target-based drug discovery, and drug repurposing are of special interest. Herein, we focused in the advances on the field of SBDD targeting arboviruses such as dengue, yellow fever, zika and chikungunya enzymes of the RNA replication complex (RC) and enzymes involved in a variety of pathways essential to ensure parasitic survival in the host, for malaria, Chagas e leishmaniasis diseases. We also highlighted successful examples such as promising new inhibitors and molecules already in preclinical/clinical phase tests, major gaps in the field and perspectives for the future of drug design for tropical diseases. (AU)

FAPESP's process: 16/19712-9 - Structural characterization of Zika virus proteins and search for antiviral agents
Grantee:Andre Schutzer de Godoy
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/05130-3 - Construction and characterization of a ZIKV sub-genomic replicon system for the discovery of antiviral agents.
Grantee:Rafaela Sachetto Fernandes
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 15/18192-9 - Discovery and development of Antimalarial Drugs: Structural Biology, Medicinal Chemistry and Parasitology
Grantee:Anna Caroline Campos Aguiar
Support Opportunities: Scholarships in Brazil - Post-Doctoral